Rethnam Ulfin, Yesupalan Rajam Sheeja
Department of Orthopaedics, Glan Clwyd Hospital, Rhyl, UK.
J Med Case Rep. 2007 Aug 31;1:75. doi: 10.1186/1752-1947-1-75.
: Ranitidine is a widely used drug and is known to be well tolerated. This case report illustrates a severe anaphylactic reaction after a single intravenous dose of 50 mgs of ranitidine and highlights this unusual but life threatening adverse reaction.
A 56 year old female with acute pancreatitis and a known allergy to metronidazole and buscopan developed an anaphylaxis few minutes following the injection of ranitidine for epigastric discomfort. She went on to develop anaphylactic shock and a cardiorespiratory arrest.
She was managed with adrenaline, hydrocortisone and ventilatory support following which she had a full recovery.
Awareness of this rare but life threatening adverse reaction to a commonly used drug can avoid being caught unaware.
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