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一座山的寓言:神经毒理学的环境导论

The allegory of a mountain: an environmental introduction to neurotoxicology.

作者信息

Prockop Leon D

机构信息

Department of Neurology, USF Health, University of South Florida, Tampa, FL, USA.

出版信息

J Neurol Sci. 2007 Nov 15;262(1-2):7-14. doi: 10.1016/j.jns.2007.06.031. Epub 2007 Aug 31.

Abstract

Overall, the area of human neurotoxicity offers significant difficulties as well as challenges in our attempts to maintain or enhance human well being. Many of the substances to which humans are being exposed are relatively new to the environment, i.e., the products of a sophisticated industrial development. As a result humans are exposed to volatile organic compounds not previously present in our environment in significant amounts. It is important to maintain our industrial complex and the economic growth of our society. The use of volatile organic compounds is often important to the success of the industry. However, it is also important for us to determine what concentration of a given substance may produce short-term effects or chronic long-term effects. Human exposure to these potentially toxic levels could then be prevented. This is especially true because once irreversible damage occurs there is no medical treatment that can lead to improvement. Therefore, prevention of neurotoxic injury is essential.

摘要

总体而言,人类神经毒性领域在我们试图维持或增进人类福祉的过程中带来了巨大的困难和挑战。人类接触的许多物质对环境来说相对较新,即复杂工业发展的产物。因此,人类接触到了以前在我们环境中不存在大量的挥发性有机化合物。维持我们的工业综合体和社会经济增长很重要。挥发性有机化合物的使用对该行业的成功往往很重要。然而,对我们来说,确定给定物质的何种浓度可能产生短期影响或慢性长期影响也很重要。这样就可以防止人类接触这些潜在的有毒水平。尤其如此,因为一旦发生不可逆转的损害,就没有任何医疗手段可以带来改善。因此,预防神经毒性损伤至关重要。

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