基于人群的磨牙后三角鳞状细胞癌治疗结果研究。
Population-based study of treatment outcomes in squamous cell carcinoma of the retromolar trigone.
作者信息
Binahmed Abdulaziz, Nason Richard W, Abdoh Ahmed A, Sándor George K B
机构信息
Hospital for Sick Children and University of Toronto, Ontario, Canada.
出版信息
Oral Surg Oral Med Oral Pathol Oral Radiol Endod. 2007 Nov;104(5):662-5. doi: 10.1016/j.tripleo.2007.04.004. Epub 2007 Aug 30.
BACKGROUND
Carcinoma of the retromolar trigone is relatively uncommon. High rates of local recurrence account for a relatively poor prognosis.
STUDY DESIGN
A population-based historical cohort of 76 cases with biopsy-proven squamous cell carcinoma of the retromolar trigone were studied as a case series. Kaplan-Meier survival curves and log rank test were used for statistical analysis.
RESULTS
The mean age was 67.2 years. Fifty-six patients were male, 45% had T1 or T2 tumors, and 61% were staged as N0. Treatment included radiotherapy in 35%, surgery alone in 26%, surgery and radiotherapy in 23%, and 16% received palliative treatment. The absolute and disease-specific survivals at 5 years were 51.4% and 67.7%, respectively. In patients treated with surgery, the resection margin status predicted the overall 5-year survival (P = .027), with 75% of patients with negative margins surviving 5 years versus a survival of 0% of patients with involved margins.
CONCLUSIONS
Squamous cell carcinoma of the retromolar trigone has a poor survival rate for early-stage disease. Adequate surgical margins can improve survival.
背景
磨牙后三角区癌相对少见。局部复发率高导致预后相对较差。
研究设计
以一项基于人群的历史队列研究为基础，对76例经活检证实为磨牙后三角区鳞状细胞癌的病例进行病例系列研究。采用Kaplan-Meier生存曲线和对数秩检验进行统计分析。
结果
平均年龄为67.2岁。56例为男性，45%患有T1或T2期肿瘤，61%分期为N0。治疗方法包括35%接受放疗，26%仅接受手术，23%接受手术和放疗，16%接受姑息治疗。5年时的绝对生存率和疾病特异性生存率分别为51.4%和67.7%。在接受手术治疗的患者中，切缘状态可预测5年总生存率（P = 0.027），切缘阴性的患者5年生存率为75%，而切缘受累的患者生存率为0%。
结论
磨牙后三角区鳞状细胞癌早期生存率低。足够的手术切缘可提高生存率。
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