Verma Pradhuman, Kumar Avinash, Dixit Shantanu, Mohan Kratika, Gupta Nidhi, Mandal Gourab
Department of Oral Medicine and Radiology/Oral Pathology and Microbiology, Dr. Ziauddin Ahmad Dental College and Hospital, Aligarh Muslim University Campus, Aligarh, Uttar Pradesh, India.
Department of ENT, Noida International Institute of Medical Sciences, Greater Noida, Uttar Pradesh, India.
Ann Maxillofac Surg. 2021 Jan-Jun;11(1):80-85. doi: 10.4103/ams.ams_265_20. Epub 2021 Jul 24.
India is a high-risk region for oropharyngeal cancer (OC) due to high prevalence of tobacco, betel nut, and alcohol and accounts for 30% of all new cases of oral cancer annually.
Records of all 73 diagnosed cases of different types of OC and oropharynx patients were analyzed who reported in "Tobacco cessation center"' of the Institute between January 2017 and December 2019. The patients' demographic details, blood groups, oral habits, and clinicohistological records were obtained from the medical records available in the hospital.
OC incidence was 3.75 cases/year with male-to-female ratio 3.29:1. Mean age was 51.25 ± 13.6 years. The most common site of tumour presentation was mandibular alveolar ridge. Combined use of tobacco/betal nut/alcohol constituted the major cause for the development of oral squamous cell carcinoma (OSCC). Majority patients were presented in Stage II (43.8%). Histopathological reports were suggestive of maximally well-differentiated (52.1%) OSCC. People with blood group A+ve had 3.22 times higher risk of developing OSCC compared to people of other blood groups.
Male: female ratio was reported higher than in most of other studies. Mandibular alveolus was the most frequent site because most of the patients tend to keep the tobacco quid in the buccal vestibule with close proximity to alveolus. The relative downregulation of glycosyl transferase that is involved in the biosynthesis of A and B antigens as seen in association with tumour development could be the reason for increased OC reported in blood group A subjects.
由于烟草、槟榔和酒精的高流行率，印度是口咽癌（OC）的高风险地区，每年占所有口腔癌新病例的30%。
分析了2017年1月至2019年12月期间在该研究所“戒烟中心”报告的所有73例不同类型OC和口咽患者的诊断记录。从医院现有的病历中获取患者的人口统计学细节、血型、口腔习惯和临床组织学记录。
OC发病率为3.75例/年，男女比例为3.29:1。平均年龄为51.25±13.6岁。肿瘤最常见的表现部位是下颌牙槽嵴。烟草/槟榔/酒精的联合使用是口腔鳞状细胞癌（OSCC）发生的主要原因。大多数患者处于II期（43.8%）。组织病理学报告提示为高分化（52.1%）OSCC。与其他血型的人相比，A+血型的人患OSCC的风险高3.22倍。
据报道，男女比例高于大多数其他研究。下颌牙槽是最常见的部位，因为大多数患者倾向于将烟草块放在靠近牙槽的颊前庭。如与肿瘤发展相关所见，参与A和B抗原生物合成的糖基转移酶相对下调可能是A血型受试者OC报告增加的原因。
