产后早期同胞剥夺对成年大鼠空间学习和记忆的性别及年龄依赖性影响。
Sex- and age-dependent effects of early postnatal sibling deprivation on spatial learning and memory in adult rats.
作者信息
Li Yan-Qin, Wang Xiao-Yi, Zhai Hai-Feng, Zhang Xiang Yang, Kosten Therese, Lu Lin
机构信息
National Institute on Drug Dependence, Peking University, Beijing 100083, China.
出版信息
Behav Brain Res. 2008 Jan 10;186(1):138-42. doi: 10.1016/j.bbr.2007.07.028. Epub 2007 Jul 27.
In this study, we investigated the effects of early postnatal sibling deprivation (EPSD) on spatial learning and memory in adult rats. Litters were culled to one pup with its mother on postnatal day (PN) 1 or 7 and their spatial learning and memory ability were examined with Morris water maze in adult. EPSD on PN1 improved, but on PN7 impaired performance of the spatial learning task in adult female rats. However, EPSD did not have any effect on the spatial learning ability in adult male rats.
在本研究中，我们调查了产后早期同胞剥夺（EPSD）对成年大鼠空间学习和记忆的影响。在出生后第1天（PN）或第7天，将一窝幼崽减少至一只幼崽及其母亲，并在成年后用莫里斯水迷宫测试它们的空间学习和记忆能力。出生后第1天的EPSD提高了成年雌性大鼠空间学习任务的表现，但出生后第7天的EPSD则损害了其表现。然而，EPSD对成年雄性大鼠的空间学习能力没有任何影响。
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