Chopard Gilles, Pitard Alexandre, Ferreira Sabrina, Vanholsbeeck Geraldine, Rumbach Lucien, Galmiche Jean
Department of Neurology, Besançon University Hospital-Jean Minjoz, Besançon, France.
J Am Geriatr Soc. 2007 Sep;55(9):1426-30. doi: 10.1111/j.1532-5415.2007.01271.x.
To assess the accuracy of combining the Memory Impairment Screen (MIS) with the Isaacs Set Test (IST) in distinguishing subjects with dementia from controls without dementia.
The weighted sum of MIS and IST scores was calculated, and the logical "or" rule combination was performed using two different patient and control samples. Combination results were compared with each test used alone and with Mini-Mental State Examination to detect all types of dementias.
Database of the Regional Network for Diagnostic Aid and Management of Patients with Cognitive Impairment in the Franche-Comté, France, geographical area.
A cohort of 444 patients with Alzheimer's disease, non-Alzheimer's dementia, and reversible dementia and 311 controls.
Sensitivity, specificity, positive predictive value, and negative predictive value were calculated for the combination of these two tests.
The weighted sum had overall sensitivities of 0.92 and 0.84 for mild cases, with a specificity of 0.92. The "or" rule had overall sensitivities of 0.92 and 0.89 for mild cases, with a specificity of 0.90. This pairing requires no more than 5 minutes. Its scoring is simple with the "or" rule combination.
The combination of MIS and IST could be a useful tool for screening dementias. The "or" rule combination seems particularly adapted to medical practice.
评估将记忆障碍筛查量表（MIS）与艾萨克斯成套测验（IST）相结合在区分痴呆患者与非痴呆对照者方面的准确性。
计算MIS和IST分数的加权总和，并使用两个不同的患者和对照样本进行逻辑“或”规则组合。将组合结果与单独使用的每项测试以及简易精神状态检查表进行比较，以检测所有类型的痴呆症。
法国弗朗什-孔泰地区认知障碍患者诊断辅助与管理区域网络数据库。
444例患有阿尔茨海默病、非阿尔茨海默病痴呆和可逆性痴呆的患者以及311名对照者。
计算这两项测试组合的灵敏度、特异度、阳性预测值和阴性预测值。
加权总和对轻度病例的总体灵敏度分别为0.92和0.84，特异度为0.92。“或”规则对轻度病例的总体灵敏度分别为0.92和0.89，特异度为0.90。这种配对所需时间不超过5分钟。采用“或”规则组合时其评分简单。
MIS和IST的组合可能是一种有用的痴呆症筛查工具。“或”规则组合似乎特别适用于医疗实践。
