衰老：全在大脑吗？

Aging: all in the head?

作者信息

Bartke Andrzej

机构信息

Departments of Internal Medicine and Physiology, Southern Illinois University School of Medicine, Springfield, IL 62794-9628, USA.

出版信息

Cell Metab. 2007 Sep;6(3):153-4. doi: 10.1016/j.cmet.2007.08.007.

DOI:10.1016/j.cmet.2007.08.007

PMID:17767900

Abstract

Global reduction in insulin signaling has been linked to extended life span in a range of organisms. New work on mice with brain-specific or whole-body reductions in insulin receptor substrate 2 (IRS2) (Taguchi et al., 2007) points to a role for insulin/IGF-1 signaling in the central control of mammalian aging.

摘要

胰岛素信号的整体减弱与一系列生物体寿命的延长有关。针对胰岛素受体底物2（IRS2）在大脑中特异性或全身表达减少的小鼠开展的新研究（田口等人，2007年）表明，胰岛素/胰岛素样生长因子-1信号在哺乳动物衰老的中枢控制中发挥作用。