Wang J Y
Department of Pediatrics, College of Medicine, National Cheng-Kung University, Taiwan, Republic of China.
Asian Pac J Allergy Immunol. 1991 Jun;9(1):51-6.
We have studied the bronchial hyperresponsiveness (BHR) of children with normal controls and asthma by methacholine inhalation challenge, using a forced oscillation method. Four parameters, respiratory conductance (Grs), bronchial responsiveness (PD35Grs), bronchial sensitivity (Dmin) and reactivity (SGrs) were studied. There were three patterns of dose-response curves identified in this study, which were significantly correlated to the clinical severity of asthma. (r = 0.846, p less than 0.001, Spearman's rank correlation). There were significant negative correlations between control Rrs (Rrs cont.) and age (r = 0.514, p less than 0.001) or body height (r = 0.685, p less than 0.001). Positive correlations between SGrs and subjects' age (r = 0.457, p less than 0.001) and body height (r = 0.496, p less than 0.001) were also noted. In the normal controls, Dmin and PD35Grs were over 25 units and 50 units, respectively. The Grs for normal children was statistically higher than that of asthmatic children (p less than 0.05). In the asthmatic children, there were significant differences among all subgroups in PD35Grs (p less than 0.001) and Dmin (p less than 0.01). In summary, the bronchial provocation test using the forced oscillation technique is simple, fast and easy to be applied to children. In addition to being capable of investigating BHR, it may offer valuable information for the clinical diagnosis and treatment of asthmatic children.
我们通过吸入乙酰甲胆碱激发试验，采用强迫振荡法，对正常对照儿童和哮喘儿童的支气管高反应性（BHR）进行了研究。研究了四个参数，即呼吸传导率（Grs）、支气管反应性（PD35Grs）、支气管敏感性（Dmin）和反应性（SGrs）。本研究确定了三种剂量反应曲线模式，它们与哮喘的临床严重程度显著相关。（r = 0.846，p < 0.001，Spearman等级相关性）。对照Rrs（Rrs cont.）与年龄（r = 0.514，p < 0.001）或身高（r = 0.685，p < 0.001）之间存在显著负相关。还注意到SGrs与受试者年龄（r = 0.457，p < 0.001）和身高（r = 0.496，p < 0.001）之间存在正相关。在正常对照中，Dmin和PD35Grs分别超过25单位和50单位。正常儿童的Grs在统计学上高于哮喘儿童（p < 0.05）。在哮喘儿童中，所有亚组在PD35Grs（p < 0.001）和Dmin（p < 0.01）方面存在显著差异。总之，采用强迫振荡技术的支气管激发试验简单、快速，易于应用于儿童。除了能够研究BHR外，它还可能为哮喘儿童的临床诊断和治疗提供有价值的信息。
