Mitchell J B, Meaney M J
Developmental Neuroendocrinology Laboratory, Douglas Hospital Research Center, Montréal, Québec, Canada.
Behav Neurosci. 1991 Dec;105(6):798-803. doi: 10.1037//0735-7044.105.6.798.
In the forced swimming test, adrenal hormones regulate immobility time during a test swim given 24 hr after the initial training swim (e.g., the deficit in adrenalectomized animals is reduced when animals are given corticosterone [B] immediately after the training session). In this study, adrenalectomy decreased and B restored immobility during the test swims. The effects of adrenalectomy were completely reversed by 1 mg/kg doses of B, which results in plasma B levels that are comparable to values under basal resting conditions. Higher doses of B had no further effect. B given before or immediately after training partially reversed the effects of adrenalectomy. The complete reversal of the effects of adrenalectomy, however, required the presence of B during both training and testing, suggesting that B plays a role in the consolidation-retention and retrieval of the immobility response.
在强迫游泳试验中，肾上腺激素在初次训练游泳24小时后的测试游泳期间调节不动时间（例如，当动物在训练后立即给予皮质酮[B]时，肾上腺切除动物的缺陷会减少）。在本研究中，肾上腺切除术减少了测试游泳期间的不动时间，而B恢复了不动时间。肾上腺切除术的影响被1mg/kg剂量的B完全逆转，这导致血浆B水平与基础静息条件下的值相当。更高剂量的B没有进一步影响。在训练前或训练后立即给予B可部分逆转肾上腺切除术的影响。然而，肾上腺切除术影响的完全逆转需要在训练和测试期间都有B存在，这表明B在不动反应的巩固-保持和提取中起作用。
