Bozhko G Kh, Kulabukhov V M, Voloshin P V
Biokhimiia. 1991 Oct;56(10):1886-93.
Using gradient gel electrophoresis, the levels of major classes of rabbit blood sera lipoproteins were studied over a period of 28 days. Hypercholesterolemia persisted up to the 4th day with a subsequent decrease. This was paralleled with an increase in the levels of triglyceride-rich and apoB-containing particles. The decrease of the electrophoretic mobility of low density lipoproteins correlated with an increased content of the intermediate fraction. On the 28th day after the beginning of experiment the concentration of total high density lipoproteins showed an increase. The subfractional redistribution of HDL3 and HDL2 subclasses pointed to the stimulation of the accepting process and the overall reverse cholesterol transport system. A comparison of experimental results with literary data allowed to conclude that the relative decrease of the serum cholesterol level typical of hypercholesterolemia of one month duration is due to the activation of specific and nonspecific preventive mechanisms.
采用梯度凝胶电泳法，对家兔血清脂蛋白主要类别水平进行了为期28天的研究。高胆固醇血症持续到第4天，随后下降。这与富含甘油三酯和含载脂蛋白B颗粒水平的增加相平行。低密度脂蛋白电泳迁移率的降低与中间组分含量的增加相关。实验开始后第28天，总高密度脂蛋白浓度升高。高密度脂蛋白3和高密度脂蛋白2亚类的亚组分重新分布表明接受过程和整体逆向胆固醇转运系统受到刺激。将实验结果与文献数据进行比较后得出结论，持续一个月的高胆固醇血症中血清胆固醇水平的相对降低是由于特异性和非特异性预防机制的激活。
