Schinstine M, Kawaja M D, Gage F H
Department of Neurosciences, University of California, San Diego, La Jolla 92093-0624.
Prog Growth Factor Res. 1991;3(1):57-66. doi: 10.1016/0955-2235(91)90013-t.
To date, a number of different growth factors (e.g. nerve growth factor, brain-derived neurotrophic factor, neurotrophin-3, ciliary neurotrophic factor, and fibroblast growth factor) have been shown to act as a neurotrophic and/or neurotrophic agents on distinct neuronal populations within the peripheral and central nervous system. Knowledge as to how most of these factors influence the development and regeneration of growth factor-sensitive neurons has been obtained from in vitro examination. A new approach that can be used to assess the effects of growth factors on neuronal groups in vivo is the combined use of gene transfer and intracerebral grafting techniques. The present article explores the potential use of grafting genetically modified fibroblasts within the nervous system as a delivery method for growth factors.
迄今为止，已证实多种不同的生长因子（如神经生长因子、脑源性神经营养因子、神经营养素-3、睫状神经营养因子和成纤维细胞生长因子）可作为神经营养和/或营养因子作用于外周和中枢神经系统内不同的神经元群体。关于这些因子中大多数如何影响生长因子敏感神经元的发育和再生的知识是通过体外研究获得的。一种可用于评估生长因子对体内神经元群体作用的新方法是基因转移和脑内移植技术的联合应用。本文探讨了在神经系统内移植基因修饰的成纤维细胞作为生长因子递送方法的潜在用途。
