辛伐他汀对IIB型高脂蛋白血症患者低密度脂蛋白颗粒表观大小的影响。

Effect of simvastatin on the apparent size of LDL particles in patients with type IIB hyperlipoproteinemia.

作者信息

Zhao S P, Hollaar L, van 't Hooft F M, Smelt A H, Gevers Leuven J A, van der Laarse A

机构信息

Department of Cardiology, University Hospital, Leiden, The Netherlands.

出版信息

Clin Chim Acta. 1991 Dec 16;203(2-3):109-17. doi: 10.1016/0009-8981(91)90283-i.

DOI:10.1016/0009-8981(91)90283-i

PMID:1777975

Abstract

After 15 weeks of simvastatin therapy (20 mg/day), low density lipoprotein particle size in sera of 16 patients with type IIb hyperlipoproteinemia increased significantly from 233 +/- 5.0 A to 237 +/- 7.0 A (P less than 0.05), analyzed by 2-16% polyacrylamide gradient gel electrophoresis. Under simvastatin therapy the concentrations of total cholesterol, total triglyceride, very low density lipoprotein cholesterol and triglyceride, low density lipoprotein cholesterol and apolipoprotein B in serum fell significantly by 30%, 30%, 43%, 28%, 36% and 26%, respectively, and the concentration of high density lipoprotein cholesterol rose significantly by 14%. The changes of low density lipoprotein particle size induced by simvastatin therapy were correlated best with the changes of very low density lipoprotein triglyceride concentration (r2 = 0.438, P less than 0.01). Our results suggest that simvastatin therapy, additionally to a reduction of the serum cholesterol concentration, increases low density lipoprotein particle size which may contribute to reduction of the risk of coronary heart disease in patients with type IIb hyperlipoproteinemia.

摘要

在辛伐他汀治疗15周（20毫克/天）后，通过2 - 16%聚丙烯酰胺梯度凝胶电泳分析，16例IIb型高脂蛋白血症患者血清中的低密度脂蛋白颗粒大小从233±5.0埃显著增加至237±7.0埃（P＜0.05）。在辛伐他汀治疗下，血清中总胆固醇、总甘油三酯、极低密度脂蛋白胆固醇和甘油三酯、低密度脂蛋白胆固醇和载脂蛋白B的浓度分别显著下降30%、30%、43%、28%、36%和26%，而高密度脂蛋白胆固醇的浓度显著上升14%。辛伐他汀治疗引起的低密度脂蛋白颗粒大小变化与极低密度脂蛋白甘油三酯浓度变化的相关性最佳（r2 = 0.438，P＜0.01）。我们的结果表明，辛伐他汀治疗除了降低血清胆固醇浓度外，还会增加低密度脂蛋白颗粒大小，这可能有助于降低IIb型高脂蛋白血症患者患冠心病的风险。