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抑制蛋白质合成:导致铁吸收受损的一种机制。

Inhibition of protein synthesis: a mechanism for the production of impaired iron absorption.

出版信息

Science. 1966 Jul 15;153(3733):315-6. doi: 10.1126/science.153.3733.315.

Abstract

Treatment of rats with cycloheximide results in a defect in intestinal iron transport. A similar defect occurs after the parenteral administration of iron. Under both conditions there is impaired uptake of iron into the mucosal cells as well as defective transfer from the intestinal mucosa. It is suggested that the interference in iron transport may be due to a deficiency of an unidenti-fild carrier Substance.

摘要

用环己亚胺处理大鼠会导致肠道铁转运缺陷。静脉内给予铁后也会发生类似的缺陷。在这两种情况下,铁进入粘膜细胞的摄取都受到损害,而且从肠粘膜的转移也有缺陷。据认为,铁转运的干扰可能是由于未鉴定的载体物质缺乏所致。

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