阿片类药物成瘾者及其家庭成员中的酒精中毒和抑郁症

Alcoholism and depressive disorders in opioid addicts and their family members.

作者信息

Kosten T R, Kosten T A, Rounsaville B J

机构信息

Substance Abuse Treatment Unit, Connecticut Mental Health Center, New Haven.

出版信息

Compr Psychiatry. 1991 Nov-Dec;32(6):521-7. doi: 10.1016/0010-440x(91)90031-7.

DOI:10.1016/0010-440x(91)90031-7

PMID:1778079

Abstract

The co-occurrence of alcoholism and depression was examined in 201 opioid addicts and their 877 first-degree relatives using direct interviews and structured family history based on the Schedule for Affective Disorders and Schizophrenia (SADS) Research Diagnostic Criteria (RDC) method. Familial alcoholism was more frequent in alcoholic than nonalcoholic proband addicts, and primary depression was more frequent in relatives of depressed than nondepressed addicts. An association was suggested between secondary, but not primary, depression and alcoholism in females.

摘要

采用基于情感障碍和精神分裂症日程表（SADS）研究诊断标准（RDC）方法的直接访谈和结构化家族史，对201名阿片类药物成瘾者及其877名一级亲属中酒精成瘾与抑郁症的共病情况进行了研究。与非酒精成瘾先证者相比，酒精成瘾先证者中的家族性酒精成瘾更为常见；与非抑郁成瘾者的亲属相比，抑郁成瘾者的亲属中原发性抑郁症更为常见。女性继发性抑郁症（而非原发性抑郁症）与酒精成瘾之间存在关联。