Luthar S S, Rounsaville B J
Department of Psychiatry, Yale University, New Haven, Connecticut 06519.
Int J Addict. 1993 Apr;28(5):415-34. doi: 10.3109/10826089309039639.
Vulnerability to drug misuse and psychopathology was explored among 673 siblings of 298 opioid-addicted probands. Disorders were evaluated based on family history information obtained from the proband. Results indicated that (1) siblings of cocaine misusers showed high vulnerability to developing drug misuse, alcoholism, and antisocial personality disorder; (2) siblings of probands with specific comorbid diagnoses were vulnerable to developing a range of disorders (no specificity of aggregation was found); (3) proband major depression was related to a broad spectrum of sibling disorders; (4) the presence of a major psychiatric disorder was strongly associated with substance misuse among siblings; (5) psychopathology appeared to precede drug misuse in terms of age of onset. These findings corroborate those previously obtained with siblings of opioid addicts, and they are discussed in terms of implications for the classification and treatment of substance misuse.
在298名阿片类药物成瘾先证者的673名兄弟姐妹中，对药物滥用和精神病理学易感性进行了探究。根据从先证者那里获得的家族史信息对疾病进行评估。结果表明：（1）可卡因滥用者的兄弟姐妹在发展为药物滥用、酒精中毒和反社会人格障碍方面表现出高易感性；（2）患有特定共病诊断的先证者的兄弟姐妹易患一系列疾病（未发现聚集特异性）；（3）先证者的重度抑郁症与广泛的兄弟姐妹疾病有关；（4）严重精神障碍的存在与兄弟姐妹中的物质滥用密切相关；（5）就发病年龄而言，精神病理学似乎先于药物滥用出现。这些发现证实了先前在阿片类药物成瘾者的兄弟姐妹中获得的发现，并根据对物质滥用的分类和治疗的影响进行了讨论。
