Gonska B D, Brune S, Bethge K P, Kreuzer H
Department of Cardiology, University of Goettingen, Germany.
Eur Heart J. 1991 Dec;12(12):1257-65. doi: 10.1093/eurheartj/12.12.1257.
Catheter ablation by radiofrequency energy was carried out in 10 patients with one type of recurrent monomorphic sustained ventricular tachycardia resistant to medical antiarrhythmic management. Electrophysiological studies before ablation included activation and pace-mapping. In all patients, the origin of the tachycardia was localized in the left ventricle: in the septum in six, at the posterolateral wall in three and anterobasal in one. The earliest onset of endocardial activation preceding the QRS complex during ventricular tachycardia ranged between -45 and -90 ms. Transcatheter ablation was performed with a bipolar or quadripolar catheter using a radiofrequency generator (HAT 100, Osypka). No complications occurred during the ablation procedure. Thereafter, in all patients, the clinical tachycardia was no longer inducible by programmed stimulation. During a follow-up period of 22 to 32 months including eight patients, the tachycardia recurred in two; one of these patients subsequently died suddenly. A third patient had one episode of a new type of sustained ventricular tachycardia some hours after catheter ablation. In the remaining patients, there was no recurrence of symptomatic tachycardia under maintenance of the antiarrhythmic management which, prior to ablation had been ineffective. Thus, our preliminary results suggest that radiofrequency catheter ablation might be beneficial for these high risk patients.
对10例患有一种对药物抗心律失常治疗耐药的复发性单形性持续性室性心动过速的患者进行了射频能量导管消融术。消融术前的电生理研究包括激动标测和起搏标测。所有患者的室性心动过速起源均位于左心室:6例位于室间隔,3例位于后侧壁,1例位于前基底。室性心动过速期间QRS波群之前最早的心内膜激动起始时间在-45至-90毫秒之间。使用射频发生器(HAT 100,Osypka)通过双极或四极导管进行经导管消融。消融过程中未发生并发症。此后,所有患者经程序刺激均不再诱发临床室性心动过速。在包括8例患者的22至32个月的随访期内,2例患者室性心动过速复发;其中1例患者随后猝死。第3例患者在导管消融术后数小时出现1次新型持续性室性心动过速发作。其余患者在维持消融术前无效的抗心律失常治疗的情况下,无症状性心动过速复发。因此,我们的初步结果表明,射频导管消融术可能对这些高危患者有益。