Vermeulen Jefrey, Akkersdijk George P, Gosselink Martijn P, Hop Wim C J, Mannaerts Guido H, van der Harst Erwin, Coene Peter-Paul L O, Weidema Wibo F, Lange Johan F
Department of Surgery, MCRZ St. Clara Hospital and Zuider Hospital, Rotterdam, The Netherlands.
Dig Surg. 2007;24(5):361-6. doi: 10.1159/000107719. Epub 2007 Aug 30.
Mortality and morbidity rates of acute perforated diverticulitis remain high. The ideal treatment is still controversial. The object of this study was to compare patients with perforated diverticulitis treated either by resection with primary anastomosis (PA) or Hartmann's procedure (HP).
A multicenter study was carried out on 200 consecutive patients with acute perforated diverticulitis who were presented in the surgical units of four affiliated teaching hospitals in Rotterdam, The Netherlands, between 1995 and 2005. Mortality and morbidity were compared in relation to type of surgery, ASA classification, age, gender, Mannheim Peritonitis Index (MPI), Hinchey score, surgeon's experience, and the time of operation.
There was a tendency for more severely affected patients (Hinchey, MPI, ASA and age) to undergo HP. Multivariate logistic regression analysis showed no significant difference in mortality between HP and PA. After HP, more patients needed one or more reinterventions to treat postoperative complications compared to PA. Besides, HP resulted in a longer total hospital and intensive care unit stay. Specialist colorectal surgeons performed significantly more frequently a PA instead of a HP and had fewer postoperative complications than general surgeons. The time of operation did not influence the choice of surgical procedure.
Selected patients with perforated diverticulitis can be managed well by PA, as it does not seem to be inferior to HP in terms of severe postoperative complications that need surgical or radiological reintervention and mortality. This decision should be made while taking into account the patient's concomitant diseases, response on preoperative resuscitation and the availability of a surgeon experienced in colorectal surgery.
急性穿孔性憩室炎的死亡率和发病率仍然很高。理想的治疗方法仍存在争议。本研究的目的是比较接受一期切除吻合术(PA)或Hartmann手术(HP)治疗的穿孔性憩室炎患者。
对1995年至2005年间在荷兰鹿特丹四家附属医院外科就诊的200例急性穿孔性憩室炎患者进行了一项多中心研究。比较了手术类型、美国麻醉医师协会(ASA)分级、年龄、性别、曼海姆腹膜炎指数(MPI)、欣奇评分、外科医生经验和手术时间与死亡率和发病率的关系。
病情较重的患者(欣奇评分、MPI、ASA分级和年龄)倾向于接受HP治疗。多因素逻辑回归分析显示,HP和PA的死亡率无显著差异。与PA相比,HP术后更多患者需要一次或多次再次干预以治疗术后并发症。此外,HP导致总住院时间和重症监护病房住院时间更长。结直肠专科医生进行PA手术的频率明显高于HP,且术后并发症少于普通外科医生。手术时间不影响手术方式的选择。
对于选定的穿孔性憩室炎患者,PA可以取得良好的治疗效果,因为在需要手术或放射介入治疗的严重术后并发症和死亡率方面,PA似乎并不逊色于HP。做出这一决定时应考虑患者的合并疾病、术前复苏的反应以及结直肠手术经验丰富的外科医生的可用性。