Ariyoshi Yasunori, Miyatake Shin-Ichi, Kimura Yoshihiro, Shimahara Takeshi, Kawabata Shinji, Nagata Kenji, Suzuki Minoru, Maruhashi Akira, Ono Koji, Shimahara Masashi
Division of Surgery 2, Department of Dentistry and Oral Surgery, Osaka Medical College, Osaka 569-8686, Japan.
Oncol Rep. 2007 Oct;18(4):861-6.
The purpose of this clinical trial was to evaluate the utility of boron neutron capture therapy (BNCT) using epithermal neutrons for cases of recurrent cancer in the oral cavity, which are not indicated for a conventional treatment modality. We enrolled four patients with local recurrence or metastasis to the regional lymph nodes after completion of initial treatments, including surgery, chemotherapy and radiotherapy. Before receiving BNCT, patients underwent 18F-p-bononophenylalanine (BPA) positron emission tomography (PET) examinations to assess the BPA accumulation ratios in tumors and normal tissues. All patients showed at least a tentative partial response, while a marked improvement in quality of life was seen in one patient. Before BNCT, that patient could not be discharged from the hospital because of eating difficulties and malaise; after treatment, he was comfortably discharged. Mild malaise, oral mucositis and alopecia were seen as mild adverse effects; however, no life-threatening systemic symptoms were observed in any of the cases. Our results suggested that BNCT is a useful treatment modality for recurrent or regionally metastasized oral cancer.
本临床试验的目的是评估使用超热中子的硼中子俘获疗法（BNCT）对不适合传统治疗方式的复发性口腔癌病例的效用。我们纳入了4例在完成包括手术、化疗和放疗在内的初始治疗后出现局部复发或区域淋巴结转移的患者。在接受BNCT之前，患者接受了18F - p - 硼代苯丙氨酸（BPA）正电子发射断层扫描（PET）检查，以评估肿瘤和正常组织中的BPA积聚率。所有患者均至少显示出初步的部分缓解，其中1例患者的生活质量有显著改善。在接受BNCT之前，该患者因进食困难和身体不适无法出院；治疗后，他顺利出院。轻度身体不适、口腔黏膜炎和脱发被视为轻度不良反应；然而，在任何病例中均未观察到危及生命的全身症状。我们的结果表明，BNCT是复发性或区域转移性口腔癌的一种有效治疗方式。
