来自真核生物结构基因组学中心的具有生物医学意义的蛋白质结构
Structures of proteins of biomedical interest from the Center for Eukaryotic Structural Genomics.
作者信息
Phillips George N, Fox Brian G, Markley John L, Volkman Brian F, Bae Euiyoung, Bitto Eduard, Bingman Craig A, Frederick Ronnie O, McCoy Jason G, Lytle Betsy L, Pierce Brad S, Song Jikui, Twigger Simon N
机构信息
Center for Eukaryotic Structural Genomics, Department of Biochemistry, University of Wisconsin-Madison, Madison, WI 53706, USA.
出版信息
J Struct Funct Genomics. 2007 Sep;8(2-3):73-84. doi: 10.1007/s10969-007-9023-6. Epub 2007 Sep 6.
The Center for Eukaryotic Structural Genomics (CESG) produces and solves the structures of proteins from eukaryotes. We have developed and operate a pipeline to both solve structures and to test new methodologies. Both NMR and X-ray crystallography methods are used for structure solution. CESG chooses targets based on sequence dissimilarity to known structures, medical relevance, and nominations from members of the scientific community. Many times proteins qualify in more than one of these categories. Here we review some of the structures that have connections to human health and disease.
真核生物结构基因组学中心（CESG）负责解析真核生物蛋白质的结构。我们开发并运行了一套用于解析结构和测试新方法的流程。核磁共振（NMR）和X射线晶体学方法都用于结构解析。CESG根据与已知结构的序列差异、医学相关性以及科学界成员的提名来选择目标。许多蛋白质符合不止一个此类标准。在此，我们回顾一些与人类健康和疾病相关的结构。
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