Department of Genetics, Stanford University Medical School, Stanford, CA 94305-5120, USA.
Nucleic Acids Res. 2012 Jan;40(Database issue):D667-74. doi: 10.1093/nar/gkr945. Epub 2011 Nov 7.
The Candida Genome Database (CGD, http://www.candidagenome.org/) is an internet-based resource that provides centralized access to genomic sequence data and manually curated functional information about genes and proteins of the fungal pathogen Candida albicans and other Candida species. As the scope of Candida research, and the number of sequenced strains and related species, has grown in recent years, the need for expanded genomic resources has also grown. To answer this need, CGD has expanded beyond storing data solely for C. albicans, now integrating data from multiple species. Herein we describe the incorporation of this multispecies information, which includes curated gene information and the reference sequence for C. glabrata, as well as orthology relationships that interconnect Locus Summary pages, allowing easy navigation between genes of C. albicans and C. glabrata. These orthology relationships are also used to predict GO annotations of their products. We have also added protein information pages that display domains, structural information and physicochemical properties; bibliographic pages highlighting important topic areas in Candida biology; and a laboratory strain lineage page that describes the lineage of commonly used laboratory strains. All of these data are freely available at http://www.candidagenome.org/. We welcome feedback from the research community at candida-curator@lists.stanford.edu.
《念珠菌基因组数据库》(CGD,http://www.candidagenome.org/)是一个基于互联网的资源,提供了对真菌病原体白色念珠菌和其他念珠菌物种的基因组序列数据和经过人工注释的基因和蛋白质功能信息的集中访问。近年来,随着念珠菌研究的范围、测序菌株和相关物种的数量的增加,对扩展基因组资源的需求也在增加。为了满足这一需求,CGD 的功能已不仅仅局限于存储白色念珠菌的数据,现在还整合了来自多个物种的数据。本文介绍了多物种信息的整合,其中包括经过注释的基因信息和光滑念珠菌的参考序列,以及连接 Locus Summary 页面的同源关系,从而可以方便地在白色念珠菌和光滑念珠菌的基因之间进行导航。这些同源关系也用于预测它们产物的 GO 注释。我们还添加了蛋白质信息页面,显示结构域、结构信息和物理化学性质;显示念珠菌生物学中重要主题领域的文献页面;以及一个实验室菌株谱系页面,描述常用实验室菌株的谱系。所有这些数据都可以在 http://www.candidagenome.org/ 上免费获得。我们欢迎研究界通过 candida-curator@lists.stanford.edu 向我们提供反馈。