Hirano T, Manabe T, Ando K, Yamaki K, Yoshimura T, Tobe T
First Department of Surgery, Faculty of Medicine, Kyoto University, Japan.
Int Surg. 1991 Oct-Dec;76(4):250-2.
To investigate the effect of surgical stress on the endocrine pancreas, we evaluated the changes in glucose-stimulated insulin release from the isolated perfused pancreas 4 and 7 days after laparotomy. Four days after laparotomy, insulin response to a glucose load was poor, and integrated insulin release was significantly less in the first and third phase of stimulation than in the normal rats. At 7 days, however, insulin response to a glucose load was augmented, and the integrated insulin release was significantly increased in all the phases of stimulation. These results indicate that in the early phase after surgical stress there is an impaired insulin response to a glucose load and that in the recovery stage after surgery, there is an augmented insulin response to a glucose load.
为研究手术应激对内分泌胰腺的影响，我们评估了剖腹术后4天和7天从离体灌注胰腺释放的葡萄糖刺激胰岛素的变化。剖腹术后4天，对葡萄糖负荷的胰岛素反应较差，刺激的第一阶段和第三阶段的胰岛素总释放量明显低于正常大鼠。然而，在第7天，对葡萄糖负荷的胰岛素反应增强，刺激各阶段的胰岛素总释放量均显著增加。这些结果表明，手术应激早期对葡萄糖负荷的胰岛素反应受损，而在术后恢复阶段，对葡萄糖负荷的胰岛素反应增强。
