Hirano T, Manabe T, Ando K, Yoshimura T, Tobe T
First Department of Surgery, Faculty of Medicine, Kyoto University.
Nihon Shokakibyo Gakkai Zasshi. 1990 Apr;87(4):1034-9.
To investigate the functional changes of endocrine pancreas in the early stage after partial hepatectomy, we evaluated the changes in the secretion of insulin to glucose load in perfused rat pancreas at 4 and 7 days after about 70% hepatectomy. Insulin responses to glucose load were significantly augmented at 4 days compared with both the normal and sham-operation rats and at 7 days also significantly augmented compared with the normal rats. These results are in accordance with the morphological changes of islet and indicate that in the early stage after hepatectomy, the response of islet B-cells to glucose load are increased in order to support the glucose metabolism in this stage. Thus, insulin seems to play an important role in the regenerating liver after hepatectomy and these changes seem to be one of the adaptation of endocrine pancreas after hepatectomy to support the regenerating liver.
为研究部分肝切除术后早期内分泌胰腺的功能变化，我们评估了约70%肝切除术后4天和7天灌注大鼠胰腺中胰岛素对葡萄糖负荷分泌的变化。与正常大鼠和假手术大鼠相比，4天时胰岛素对葡萄糖负荷的反应显著增强，与正常大鼠相比，7天时也显著增强。这些结果与胰岛的形态学变化一致，表明肝切除术后早期，胰岛B细胞对葡萄糖负荷的反应增强，以支持该阶段的葡萄糖代谢。因此，胰岛素似乎在肝切除术后再生肝脏中起重要作用，这些变化似乎是肝切除术后内分泌胰腺支持再生肝脏的适应性变化之一。
