Science. 1995 Jul 7;269(5220):54-7. doi: 10.1126/science.269.5220.54.
Amorphous iron sulfide minerals containing either 500 or 3000 iron atoms in each cluster have been synthesized in situ within the nanodimensional cavity of horse spleen ferritin. Iron-57 Mössbauer spectroscopy indicated that most of the iron atoms in the 3000-iron atom cores are trivalent, whereas in the 500-iron atom clusters, approximately 50 percent of the iron atoms are Fe(III), with the remaining atoms having an effective oxidation state of about +2.5. Iron K-edge extended x-ray absorption fine structure data for the 500-iron atom nanocomposite are consistent with a disordered array of edge-shared FeS(4) tetrahedra, connected by Fe(S)(2)Fe bridges with bond lengths similar to those of the cubane-type motif of iron-sulfur clusters. The approach used here for the controlled synthesis of bioinorganic nanocomposites could be useful for the nanoscale engineering of dispersed materials with biocompatible and bioactive properties.
在马脾铁蛋白的纳米腔室内原位合成了每个簇含有 500 或 3000 个铁原子的无定形硫化亚铁矿物。57Fe Mössbauer 光谱表明，3000 个铁原子核中大多数铁原子为三价，而在 500 个铁原子簇中，约 50%的铁原子为 Fe(III)，其余原子的有效氧化态约为+2.5。500 个铁原子纳米复合材料的铁 K 边扩展 X 射线吸收精细结构数据与边缘共享 FeS(4)四面体的无序排列一致，通过 Fe(S)(2)Fe 桥连接，键长与笼型铁硫簇的 motif 相似。这里用于生物无机纳米复合材料可控合成的方法可能对具有生物相容性和生物活性的分散材料的纳米级工程有用。
