内皮素结合抑制剂BE - 18257A和BE - 18257B II. 结构测定

Endothelin-binding inhibitors, BE-18257A and BE-18257B II. Structure determination.

作者信息

Nakajima S, Niiyama K, Ihara M, Kojiri K, Suda H

机构信息

Central Research, Banyu Pharmaceutical Co., Ltd., Tokyo, Japan.

出版信息

J Antibiot (Tokyo). 1991 Dec;44(12):1348-56. doi: 10.7164/antibiotics.44.1348.

DOI:10.7164/antibiotics.44.1348

PMID:1778787

Abstract

The structures of novel endothelin-binding inhibitors, BE-18257A and BE-18257B, were elucidated by spectral analyses and chemical studies. Both inhibitors were found to have a cyclic pentapeptide structure containing three D-form amino acid residues, namely, the structures of BE-18257A and BE-18257B were elucidated to be cyclo(-D-Glu-L-Ala-D-Val-L-Leu-D-Trp-) and cyclo(-D-Glu-L-Ala-allo-D-Ile-L-Leu-D-Trp-), respectively.

摘要

通过光谱分析和化学研究阐明了新型内皮素结合抑制剂BE - 18257A和BE - 18257B的结构。发现这两种抑制剂均具有包含三个D型氨基酸残基的环五肽结构，即BE - 18257A和BE - 18257B的结构分别被阐明为环（-D - 谷氨酸 - L - 丙氨酸 - D - 缬氨酸 - L - 亮氨酸 - D - 色氨酸-）和环（-D - 谷氨酸 - L - 丙氨酸 - 别 - D - 异亮氨酸 - L - 亮氨酸 - D - 色氨酸-）。