内皮素结合抑制剂BE-18257A和BE-18257B。I. 分类学、发酵、分离与表征。
Endothelin-binding inhibitors, BE-18257A and BE-18257B. I. Taxonomy, fermentation, isolation and characterization.
作者信息
Kojiri K, Ihara M, Nakajima S, Kawamura K, Funaishi K, Yano M, Suda H
机构信息
Exploratory Research, Banyu Pharmaceutical Co., Ltd., Tokyo, Japan.
出版信息
J Antibiot (Tokyo). 1991 Dec;44(12):1342-7. doi: 10.7164/antibiotics.44.1342.
PMID:1778786
Abstract
Two endothelin (ET)-binding inhibitors, BE-18257A and BE-18257B, which antagonized 125I-ET-1 binding to a porcine aortic smooth muscle membrane, were isolated from the mycelium of a strain of Streptomyces misakiensis. These binding inhibitors were extracted with methanol from mycelium and purified by HPLC.
摘要
从三宅链霉菌菌株的菌丝体中分离出两种内皮素（ET）结合抑制剂BE-18257A和BE-18257B，它们能拮抗125I-ET-1与猪主动脉平滑肌膜的结合。这些结合抑制剂用甲醇从菌丝体中提取，并用高效液相色谱法纯化。
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