Koyama S, Aoki S, Furukawa T, Takahashi M, Kishi K, Koike T, Moriyama Y, Hattori A, Shibata A
Department of Hematology and Oncology, Saiseikai Niigata Second Hospital.
Rinsho Ketsueki. 1991 Dec;32(12):1577-9.
A 60-year-old woman was admitted to our hospital because of gastric ulcer, anemia, and leukocytosis in November 1984. Blood cell counts on admission were as follows: RBC 407 x 10(4)/microliters, Hb 9.8 g/dl, WBC 33,000/microliters (baso 8%, eo 7%, myelo 11%, meta 2%, stab 4%, seg 54%), Plt 93.7 x 10(4)/microliters. Bone marrow showed hypercellular and myeloid hyperplasia. She was diagnosed as Ph1-chromosome positive chronic myelogenous leukemia. She received natural interferon-alpha at the dosage of 600 x 10(4) IU daily for 22 days from January 14, 1985. After March 1985, she has been given intermittent administration of interferon once in 10 to 20 days, and maintained normal blood cell counts. Cytogenetic improvement was seen on 35 months after the start of IFN and complete suppression of Ph1 chromosome was observed at July 1990 (66 months after).
一名60岁女性因胃溃疡、贫血和白细胞增多于1984年11月入院。入院时血细胞计数如下：红细胞407×10⁴/微升，血红蛋白9.8克/分升，白细胞33000/微升（嗜碱性粒细胞8%，嗜酸性粒细胞7%，中幼粒细胞11%，晚幼粒细胞2%，杆状核粒细胞4%，分叶核粒细胞54%），血小板93.7×10⁴/微升。骨髓显示细胞增多和髓系增生。她被诊断为Ph1染色体阳性慢性粒细胞白血病。1985年1月14日起，她接受了每日600×10⁴国际单位的天然α干扰素治疗，共22天。1985年3月后，她每10至20天接受一次干扰素间歇给药，并维持血细胞计数正常。干扰素开始使用35个月后出现细胞遗传学改善，1990年7月（66个月后）观察到Ph1染色体完全抑制。
