Ohyashiki J H, Kawakubo K, Ohyashiki K, Toyama K
1st Department of Internal Medicine, Tokyo Medical College.
Rinsho Byori. 1993 Dec;41(12):1305-9.
Patients with Philadelphia chromosome-positive acute leukemia (Ph + AL) were treated with natural interferon-alpha (IFN-alpha) after entering complete remission. In this study, subsequent cytogenetic analysis during complete remission in Ph + AL patients with major-BCR rearrangement revealed that the percentage of bone marrow cells with the Ph chromosome increased, while the bone marrow maintained a remission status. This cytogenetic-hematologic discrepancy led us to consider that the Ph + metaphases might be derived from cells with a non-lymphoid lineage rather than residual leukemic lymphoblasts. After administration of IFN-alpha, the percentage of bone marrow cells with a Ph chromosome decreased. Although this study is on going and we do not yet have the final results, treatment of IFN-alpha should be attempted on more patients with such a genetic abnormality.
费城染色体阳性急性白血病（Ph + AL）患者在进入完全缓解期后接受天然α干扰素（IFN-α）治疗。在本研究中，对具有主要BCR重排的Ph + AL患者完全缓解期进行的后续细胞遗传学分析显示，带有费城染色体的骨髓细胞百分比增加，而骨髓维持缓解状态。这种细胞遗传学-血液学差异使我们认为，Ph +中期细胞可能源自非淋巴细胞系细胞，而非残留的白血病淋巴母细胞。给予IFN-α后，带有费城染色体的骨髓细胞百分比下降。尽管这项研究仍在进行中，我们尚未得到最终结果，但应尝试对更多有这种基因异常的患者进行IFN-α治疗。
