Roy A
Hillside Hospital, Glen Oaks, NY 11004.
Neuropharmacology. 1991 Dec;30(12B):1441-4. doi: 10.1016/s0028-3908(11)80014-6.
Diazepam binding inhibitor (DBI) is a neuromodulatory peptide for gamma-aminobutyric acid (GABA) neurotransmission. Levels of DBI in cerebrospinal fluid (CSF) were found to be elevated in depressed patients, when compared to age- and sex-matched normal controls. Levels of the peptide, corticotropin-releasing hormone (CRH), in CSF have been found to be elevated in depressed patients. Significant positive correlations between levels of DBI and CRH in the CSF of depressed patients and normal controls were found. These data suggest the possibility that DBI may have a role in coordinating responses to stress in humans, in addition to its possible role in the pathophysiology of depression.
地西泮结合抑制剂（DBI）是一种用于γ-氨基丁酸（GABA）神经传递的神经调节肽。与年龄和性别匹配的正常对照组相比，抑郁症患者脑脊液（CSF）中的DBI水平升高。脑脊液中促肾上腺皮质激素释放激素（CRH）的水平在抑郁症患者中也被发现升高。抑郁症患者和正常对照组脑脊液中DBI和CRH水平之间存在显著的正相关。这些数据表明，DBI除了可能在抑郁症的病理生理学中发挥作用外，还可能在协调人类对应激的反应中发挥作用。
