Barbaccia M L, Costa E, Ferrero P, Guidotti A, Roy A, Sunderland T, Pickar D, Paul S M, Goodwin F K
Arch Gen Psychiatry. 1986 Dec;43(12):1143-7. doi: 10.1001/archpsyc.1986.01800120029007.
Diazepam-binding inhibitor is a novel peptide purified to homogeneity from rat and human brain. Diazepam-binding inhibitor is present, though not exclusively, in gamma-aminobutyric acid (GABA)-containing neurons where it is believed to inhibit GABAergic neurotransmission mediated by GABA by binding to the benzodiazepine-GABA receptor complex. Since an impairment of central GABAergic tone has been postulated to be associated with a number of neuropsychiatric disorders, we measured human diazepam-binding inhibitor immunoreactivity in the cerebrospinal fluid (CSF) of patients suffering from endogenous depression, schizophrenia, and dementia of the Alzheimer's type. Patients with major depression had significantly higher concentrations of human diazepam-binding inhibitor immunoreactivity in CSF when compared with age- and sex-matched normal volunteers, while no difference in CSF diazepam-binding inhibitor immunoreactivity was found in schizophrenics or patients with dementia of the Alzheimer's type when compared with controls. The possibility is discussed that the increased CSF human diazepam-binding inhibitor immunoreactivity observed in depressed patients may represent a functional disinhibition of GABAergic neurotransmission associated with depression.
地西泮结合抑制剂是一种从大鼠和人脑中纯化至同质的新型肽。地西泮结合抑制剂存在于含γ-氨基丁酸（GABA）的神经元中，虽然并非仅存在于此，据信它通过与苯二氮䓬-GABA受体复合物结合来抑制由GABA介导的GABA能神经传递。由于中枢GABA能张力受损被认为与多种神经精神疾病有关，我们测量了患有内源性抑郁症、精神分裂症和阿尔茨海默型痴呆症患者脑脊液（CSF）中的人地西泮结合抑制剂免疫反应性。与年龄和性别匹配的正常志愿者相比，重度抑郁症患者脑脊液中的人地西泮结合抑制剂免疫反应性浓度显著更高，而与对照组相比，精神分裂症患者或阿尔茨海默型痴呆症患者脑脊液中的地西泮结合抑制剂免疫反应性没有差异。文中讨论了在抑郁症患者中观察到的脑脊液中人地西泮结合抑制剂免疫反应性增加可能代表与抑郁症相关的GABA能神经传递功能去抑制的可能性。
