Marova E I, Avakian M R, Kirpatovskaia L E
Probl Endokrinol (Mosk). 1991 Sep-Oct;37(5):10-3.
Altogether 25 patients with acromegaly, 19 patients with prolactinomas, and 6 patients with nonfunctioning hypophyseal tumors (NHT) were investigated. Dopaminergic regulation of PRL, STH, TSH, LH and FSH was investigated with sulpiride (an antagonist of peripheral action) in all the patients. In acromegaly, irrespective of the presence of hyperprolactinemia, one can observe dysfunction of the central dopaminergic system (DAE) and DAE-regulation of adenohypophyseal hormones. Signs of disordered hormonal DAE-regulation are disorder of the normal ejection of PRL and pathological ejection of TSH in response to administration of DA antagonists. The results of investigations revealed both an enhanced tone of the DAE-system and insufficiency of DAE-control of hormonal secretion in patients with different hypophyseal tumors and other neuroendocrine diseases.
共对25例肢端肥大症患者、19例催乳素瘤患者和6例无功能垂体瘤（NHT）患者进行了研究。对所有患者使用舒必利（一种外周作用拮抗剂）研究了多巴胺能对催乳素（PRL）、生长激素（STH）、促甲状腺激素（TSH）、促黄体生成素（LH）和促卵泡生成素（FSH）的调节作用。在肢端肥大症中，无论是否存在高催乳素血症，均可观察到中枢多巴胺能系统（DAE）功能障碍以及腺垂体激素的DAE调节异常。激素DAE调节紊乱的迹象是，给予多巴胺拮抗剂后，PRL正常分泌紊乱以及TSH异常分泌。研究结果显示，不同垂体瘤患者和其他神经内分泌疾病患者中，DAE系统的张力增强，且DAE对激素分泌的控制不足。
