Dobracheva A D, Butrova S A
Probl Endokrinol (Mosk). 1990 May-Jun;36(3):23-8.
The role of dopamine (DA) in the secretion of gonadotropic hormones was studied in women with obesity and normal body mass. Tests with sulpiride (peripheral antagonist of DA-receptors), sulpiride LH-RH and thyroliberin were made. Basal and LH-RH-stimulated secretion of gonadotropins and prolactin (PRL) was studied to reveal the relationship of their secretion with the status of the hypothalamohypophyseal system. It was shown that the blockade of peripheral DA receptors did not result in an increase in the basal and LH-RH-stimulated secretion of LH either in healthy women or in women with obesity at the normal basal level of gonadotropic hormones. Hyperprolactinemia caused by sulpiride or LH-RH, did not lower LH secretion during the entire period of investigation. There were no differences either in the basal level of gonadotropic hormones or in their ejection in response to LH-RH administration in women with normal and excess body mass. Stimulation of PRL secretion in response to LH-RH was found in patients with exogenous-constitutional obesity and minimum signs of diencephalic pathology. Slight inhibition of PRL secretion after LH-RH administration was noted in women with obesity of hypothalamic type and unstable type of disorder of EEG. The absence of changes in PRL secretion was noted in women with strongly marked hypothalamic signs of the disease.
在肥胖和体重正常的女性中研究了多巴胺（DA）在促性腺激素分泌中的作用。使用了舒必利（DA受体外周拮抗剂）、舒必利联合促黄体生成素释放激素（LH-RH）以及促甲状腺素释放激素进行试验。研究了促性腺激素和催乳素（PRL）的基础分泌以及LH-RH刺激后的分泌情况，以揭示它们的分泌与下丘脑 - 垂体系统状态之间的关系。结果表明，在促性腺激素基础水平正常的健康女性和肥胖女性中，外周DA受体的阻断均未导致基础分泌以及LH-RH刺激后的促黄体生成素（LH）分泌增加。由舒必利或LH-RH引起的高催乳素血症在整个研究期间并未降低LH分泌。体重正常和超重的女性在促性腺激素基础水平或对LH-RH给药的反应性分泌方面均无差异。在外源性体质性肥胖且间脑病变迹象最少的患者中发现了对LH-RH刺激的PRL分泌增加。在下丘脑型肥胖且脑电图紊乱类型不稳定的女性中，观察到LH-RH给药后PRL分泌略有抑制。在疾病具有明显下丘脑体征的女性中，未发现PRL分泌有变化。
