生长激素分泌的研究VIII. α,β-亚甲基三磷酸腺苷对前列腺素诱导的大鼠垂体前叶生长激素释放及环磷酸腺苷积累的影响
Studies of growth hormone secretion VIII. Effects of alpha,beta-methylene-ATP on prostglandin induced GH release and cyclic AMP accumlation in rat anterior pituitary glands.
作者信息
Hertelendy F, Yeh M
出版信息
Prostaglandins. 1976 Feb;11(2):285-91. doi: 10.1016/0090-6980(76)90151-9.
PMID:178028
Abstract
Alpha, beta-methylene-ATP, a competitive inhibitor of adenylate cyclase of liver and fat cell membrane preparations, caused a dose related inhibition of PGE1 and PGE2-induced cyclic AMP accumulation in rat anterior pituitary explants. At the same time, this ATP analog potentiated PGE1 and PGE2-promoted growth hormone secretion. The possible functional role of prostaglandins and cyclic nucleotides in the regulation of growth hormone secretion remains to be defined.
摘要
α,β-亚甲基三磷酸腺苷是肝和脂肪细胞膜制剂中腺苷酸环化酶的竞争性抑制剂，它对大鼠垂体前叶外植体中前列腺素E1（PGE1）和前列腺素E2（PGE2）诱导的环磷酸腺苷（cAMP）积累产生剂量相关的抑制作用。同时，这种三磷酸腺苷类似物增强了PGE1和PGE2促进的生长激素分泌。前列腺素和环核苷酸在生长激素分泌调节中的可能功能作用仍有待确定。
相似文献
1
Studies of growth hormone secretion VIII. Effects of alpha,beta-methylene-ATP on prostglandin induced GH release and cyclic AMP accumlation in rat anterior pituitary glands.生长激素分泌的研究VIII. α,β-亚甲基三磷酸腺苷对前列腺素诱导的大鼠垂体前叶生长激素释放及环磷酸腺苷积累的影响
Prostaglandins. 1976 Feb;11(2):285-91. doi: 10.1016/0090-6980(76)90151-9.
2
Characteristics of the desensitization of growth hormone and cyclic AMP responses to growth hormone-releasing factor and prostaglandin E2 in rat anterior pituitary cells in culture.培养的大鼠垂体前叶细胞中生长激素及环磷酸腺苷对生长激素释放因子和前列腺素E2脱敏反应的特征
Mol Cell Endocrinol. 1986 Jun;46(1):79-89. doi: 10.1016/0303-7207(86)90072-9.
3
Specificity of the stimulatory effect of prostaglandins on hormone release in rat anterior pituitary cells in culture.前列腺素对培养的大鼠垂体前叶细胞激素释放刺激作用的特异性。
Prostaglandins. 1976 Feb;11(2):355-65. doi: 10.1016/0090-6980(76)90157-x.
4
Studies on growth hormone secretion. IX. Prostaglandins do not act like ionophores.生长激素分泌的研究。IX. 前列腺素的作用不像离子载体。
Prostaglandins. 1978 Apr;15(4):575-90. doi: 10.1016/0090-6980(78)90054-0.
5
Characteristics of action of prostaglandins on cyclic AMP accumulation in rat anterior pituitary gland.
Can J Biochem. 1975 Apr;53(4):455-60. doi: 10.1139/o75-062.
6
Mechanism of action of somatostatin: growth-hormone release [45Ca]calcium ion efflux and cyclic nucleotide metabolism of bovine anterior-pituitary slices in the presence of prostaglandin E2 and 1-methyl-3-isobutylxanthine.
Biochem Soc Trans. 1977;5(1):219-22. doi: 10.1042/bst0050219.
7
Actions of growth hormone-releasing factor and somatostatin on adenylate cyclase and growth hormone release in rat anterior pituitary.生长激素释放因子和生长抑素对大鼠垂体前叶腺苷酸环化酶及生长激素释放的作用
Mol Cell Endocrinol. 1984 Oct;37(3):277-84. doi: 10.1016/0303-7207(84)90097-2.
8
Interactions between growth hormone-releasing factor, prostaglandin E2 and somatostatin on cyclic AMP accumulation in rat adenohypophysial cells in culture.生长激素释放因子、前列腺素E2和生长抑素对培养的大鼠腺垂体细胞中环磷酸腺苷积累的相互作用。
Mol Cell Endocrinol. 1983 Dec;33(2-3):255-64. doi: 10.1016/0303-7207(83)90171-5.
9
Sex differences in the cyclic adenosine 3':5'-monophosphate and growth hormone response to growth hormone-releasing factor in vitro.体外环磷酸腺苷及生长激素对生长激素释放因子反应中的性别差异。
Biol Reprod. 1984 Dec;31(5):984-8. doi: 10.1095/biolreprod31.5.984.
10
Pituitary cyclic AMP production and mechanism of luteinizing hormone release.
FEBS Lett. 1975 Oct 15;58(1):318-21. doi: 10.1016/0014-5793(75)80288-2.
Zotero 插件