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体外环磷酸腺苷及生长激素对生长激素释放因子反应中的性别差异。

Sex differences in the cyclic adenosine 3':5'-monophosphate and growth hormone response to growth hormone-releasing factor in vitro.

作者信息

Cronin M J, Rogol A D

出版信息

Biol Reprod. 1984 Dec;31(5):984-8. doi: 10.1095/biolreprod31.5.984.

DOI:10.1095/biolreprod31.5.984
PMID:6097316
Abstract

Human pancreas tumor growth hormone-releasing factor (hpGRF) induced more cellular cyclic adenosine 3':5'-monophosphate (AMP) accumulation and growth hormone release from male than female rat anterior pituitaries in vitro. This was reflected in a change in maximal levels achieved (efficacy) rather than potency, and was not an exclusive effect of hpGRF peptide; prostaglandin E2 also exhibited these effects. These data suggest that the origin of the larger spontaneous peak growth hormone levels in male rats may be within the anterior pituitary gland.

摘要

在体外实验中，人胰腺肿瘤生长激素释放因子（hpGRF）诱导雄性大鼠垂体前叶细胞内的环磷酸腺苷（cAMP）积累以及生长激素释放的能力比雌性大鼠更强。这反映在达到的最大水平（效能）的变化上，而非效力，并且这并非hpGRF肽的独特作用；前列腺素E2也表现出这些作用。这些数据表明，雄性大鼠自发性生长激素水平较高的原因可能在于垂体前叶。

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