Migliavacca Roberta, Nucleo Elisabetta, D'Andrea Marco M, Spalla Melissa, Giani Tommaso, Pagani Laura
Dipartimento di Scienze Morfologiche Eidologiche e Cliniche, sezione di Microbiologia, Università di Pavia, Pavia, Italy.
New Microbiol. 2007 Jul;30(3):295-8.
We report the multiple detection of Proteus mirabilis isolates, from 4 different long-term care and rehabilitation facilities (LTCRFs) of Northern Italy, resistant to expanded-spectrum cephalosporins and cephamycins and producing an acquired ampC-like beta-lactamase, named CMY-16. Genotyping by PFGE showed that isolates were clonally related to each other, although not identical. In all isolates the bla(CMY16) gene was not transferable by conjugation and was found to be carried on the chromosome. These results revealed multifocal spreading of a CMY-16 producing P. mirabilis clone in Northern Italy and emphasize the emergence of similar acquired resistance determinants in the LTCRFs setting.
我们报告了从意大利北部4个不同的长期护理和康复机构（LTCRF）分离出奇异变形杆菌，这些菌株对广谱头孢菌素和头孢霉素耐药，并产生一种获得性AmpC样β-内酰胺酶，命名为CMY-16。脉冲场凝胶电泳（PFGE）基因分型显示，分离株彼此克隆相关，尽管并不完全相同。在所有分离株中，bla(CMY16)基因不能通过接合转移，且发现其位于染色体上。这些结果揭示了产CMY-16奇异变形杆菌克隆在意大利北部的多灶性传播，并强调了在LTCRF环境中出现类似获得性耐药决定因素的情况。
