Ozkan Suleyman, Akay Tankut Hakki, Gultekin Bahadir, Aslim Erdal, Arslan Ahmet, Ozdemir B Handan, Becit Necip, Tasdelen Atilay
Department of Cardiovascular Surgery, Baskent University Hospital, Ankara, Turkey.
J Card Surg. 2007 Sep-Oct;22(5):385-9. doi: 10.1111/j.1540-8191.2007.00431.x.
This study aimed to evaluate the degree and incidence of atherosclerosis in internal thoracic (ITA) and radial arteries (RA) harvested for coronary bypass grafting.
The association of major clinical events and etiological factors for atherosclerosis was investigated in 770 arterial segments obtained prospectively from 480 patients. Potential risk factors for atherosclerosis were age, gender, smoking, diabetes mellitus, peripheral vascular disease, cerebrovascular disease, chronic renal failure, hypercholesterolemia, obesity, hypertension, and a positive family history.
Six types of histological lesions have been defined; grade III or more was present in the RA in 47 (16%) patients and in the ITA in 30 (7%). The mean grade was 1.6 +/- 0.6 in the ITA and 2.1 +/- 0.9 in the RA (p < 0.001).
RA had a significantly greater prevalence of atherosclerosis than the same patients' ITA. There was a strong correlation between ITA atherosclerosis and age. The presence of calcification may lead surgeons to avoid an extra incision according to risk factors, although most of these are not predictive.
本研究旨在评估用于冠状动脉搭桥术获取的胸廓内动脉（ITA）和桡动脉（RA）中动脉粥样硬化的程度和发生率。
前瞻性地从480例患者获取770个动脉节段，研究主要临床事件与动脉粥样硬化病因学因素之间的关联。动脉粥样硬化的潜在危险因素包括年龄、性别、吸烟、糖尿病、外周血管疾病、脑血管疾病、慢性肾衰竭、高胆固醇血症、肥胖、高血压以及家族史阳性。
已定义六种组织学病变类型；47例（16%）患者的RA中存在III级或更高级别病变，30例（7%）患者的ITA中存在此类病变。ITA的平均级别为1.6±0.6，RA为2.1±0.9（p<0.001）。
RA的动脉粥样硬化患病率显著高于同一患者的ITA。ITA动脉粥样硬化与年龄之间存在强相关性。钙化的存在可能会使外科医生根据危险因素避免额外切口，尽管其中大多数并无预测性。
