在细菌细胞死亡之路上。
On the road to bacterial cell death.
作者信息
Wright Gerard D
机构信息
Department of Biochemistry and Biomedical Sciences, DeGroote School of Medicine, McMaster University, Hamilton, ON, L8N 3Z5, Canada.
出版信息
Cell. 2007 Sep 7;130(5):781-3. doi: 10.1016/j.cell.2007.08.023.
PMID:17803902
Abstract
How do antibiotics actually work? Although the primary cellular targets of many antimicrobial agents have been identified, the downstream events leading to bacterial cell death remain unclear. In this issue, Kohanski et al. (2007) provide evidence that the production of reactive oxygen species is a shared mechanism of cell death initiated by bactericidal antibiotics.
摘要
抗生素究竟是如何发挥作用的？尽管许多抗菌药物的主要细胞靶点已被确定，但导致细菌细胞死亡的下游事件仍不清楚。在本期中，科汉斯基等人（2007年）提供了证据，表明活性氧的产生是杀菌抗生素引发细胞死亡的一种共同机制。
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