Sugiura Makoto, Naganawa Shinji, Sone Michihiko, Yoshida Tadao, Nakashima Tsutomu
Department of Otorhinolaryngology, Nagoya University Graduate School of Medicine 65, Tsurumai-cho, Showa-ku, Nagoya 466-8550, Japan.
Auris Nasus Larynx. 2008 Jun;35(2):269-72. doi: 10.1016/j.anl.2007.04.004. Epub 2007 Sep 5.
A 51-year-old man had progressive hearing loss over more than 15 years. He had bilateral sensorineural hearing loss (SNHL). Computed tomography (CT) showed extensive bilateral demineralization of the cochlear capsule, which is characteristic of diffuse cochlear otosclerosis. Three-dimensional fluid-attenuated inversion recovery (3D-FLAIR) of magnetic resonance imaging before enhancement revealed high signals in the cochlea and vestibule. Postcontrast 3D-FLAIR revealed enhancement of the basal turn of the left cochlea. This is the first published case of the breakdown of the blood-labyrinth barrier in a patient with cochlear otosclerosis. Our findings suggest that the breakdown of the blood-labyrinth barrier is associated with a part of SNHL in cochlear otosclerosis.
一名51岁男性在超过15年的时间里听力逐渐丧失。他患有双侧感音神经性听力损失（SNHL）。计算机断层扫描（CT）显示双侧耳蜗广泛脱矿质，这是弥漫性耳蜗耳硬化症的特征。增强前磁共振成像的三维液体衰减反转恢复（3D-FLAIR）显示耳蜗和前庭有高信号。增强后3D-FLAIR显示左侧耳蜗底转有强化。这是首例发表的耳蜗耳硬化症患者血迷路屏障破坏的病例。我们的研究结果表明，血迷路屏障破坏与耳蜗耳硬化症中部分SNHL有关。
