John Rohan, Nelson Peter J
Division of Nephrology, New York University School of Medicine, New York, NY 10016, USA.
J Am Soc Nephrol. 2007 Oct;18(10):2628-35. doi: 10.1681/ASN.2007030273. Epub 2007 Sep 5.
Dendritic cells (DC) in nonlymphoid organs function at the crossroads of innate and adaptive immunity, self-tolerance, and tissue homeostasis. This review provides an overview of the study of DC in the kidney, tracing its history leading to the current knowledge of the origins, migration, and function of renal DC. Together, these studies suggest that renal DC play a critical role in the health and disease of the kidney, opening the way to direct targeting of renal DC for therapeutic benefit.
非淋巴器官中的树突状细胞（DC）在固有免疫和适应性免疫、自身耐受以及组织稳态的交叉点发挥作用。本综述概述了肾脏中DC的研究情况，追溯了其发展历程，直至目前对肾DC的起源、迁移和功能的认识。这些研究共同表明，肾DC在肾脏的健康和疾病中起着关键作用，为直接靶向肾DC以获得治疗益处开辟了道路。
