Rai Rekha, Peng Guang, Li Kaiyi, Lin Shiaw-Yih
ACTREC (CRI), TMC, Mumbai, Maharashtra, India.
Cancer Genomics Proteomics. 2007 Mar-Apr;4(2):99-106.
One of the most common features of cancer is genetic instability. In response to numerous DNA-damaging insults, normal cells have evolved a complex mechanism to monitor and repair DNA damage lesions to maintain genomic integrity. The defects in DNA damage response, indeed, have been shown to associate closely with tumorigenesis. This review provides an overview on the molecular events in DNA damage signaling pathway, including cell cycle checkpoint and DNA repair. The recent research discoveries on how dysfunction in DNA damage response contributes to genomic instability and cancer development are also discussed.
癌症最常见的特征之一是基因不稳定。为应对众多DNA损伤刺激，正常细胞已进化出一种复杂机制来监测和修复DNA损伤病变，以维持基因组完整性。事实上，DNA损伤反应缺陷已被证明与肿瘤发生密切相关。本综述概述了DNA损伤信号通路中的分子事件，包括细胞周期检查点和DNA修复。还讨论了关于DNA损伤反应功能障碍如何导致基因组不稳定和癌症发展的最新研究发现。
