在患有轻度认知障碍的遗忘型与非遗忘型患者中，包被血小板水平更高。

Coated-platelets are higher in amnestic versus nonamnestic patients with mild cognitive impairment.

作者信息

Prodan Calin I, Ross Elliott D, Vincent Andrea S, Dale George L

机构信息

Neurology Service, Veterans Administration Medical Center, Oklahoma City, Oklahoma, USA.

出版信息

Alzheimer Dis Assoc Disord. 2007 Jul-Sep;21(3):259-61. doi: 10.1097/WAD.0b013e31811ec11f.

DOI:10.1097/WAD.0b013e31811ec11f

PMID:17804959

Abstract

Coated-platelets, a subset of platelets produced by coactivation with both collagen and thrombin, retain intact amyloid precursor protein on their surface. We analyzed blood samples from 66 individuals with mild cognitive impairment (36 amnestic and 30 nonamnestic) for coated-platelet production. Coated-platelet levels were significantly higher in amnestic compared with nonamnestic patients (P=0.037). These findings support the hypothesis that coated-platelets may be linked to the requisite alteration in amyloid precursor protein metabolism that occurs in Alzheimer disease.

摘要

包被血小板是通过与胶原蛋白和凝血酶共同激活产生的血小板亚群，其表面保留完整的淀粉样前体蛋白。我们分析了66名轻度认知障碍患者（36名遗忘型和30名非遗忘型）的血样以检测包被血小板的产生情况。与非遗忘型患者相比，遗忘型患者的包被血小板水平显著更高（P=0.037）。这些发现支持了以下假说，即包被血小板可能与阿尔茨海默病中发生的淀粉样前体蛋白代谢的必要改变有关。