Aliotta Alessandro, Bertaggia Calderara Debora, Zermatten Maxime G, Marchetti Matteo, Alberio Lorenzo
Hemostasis and Platelet Research Laboratory, Division of Hematology and Central Hematology Laboratory, Lausanne University Hospital (CHUV) and University of Lausanne (UNIL), CH-1010 Lausanne, Switzerland.
Service de Médecine Interne, Hôpital de Nyon, CH-1260 Nyon, Switzerland.
J Clin Med. 2021 Feb 24;10(5):894. doi: 10.3390/jcm10050894.
Platelets are active key players in haemostasis. Qualitative platelet dysfunctions result in thrombocytopathies variously characterized by defects of their adhesive and procoagulant activation endpoints. In this review, we summarize the traditional platelet defects in adhesion, secretion, and aggregation. In addition, we review the current knowledge about procoagulant platelets, focusing on their role in bleeding or thrombotic pathologies and their pharmaceutical modulation. Procoagulant activity is an important feature of platelet activation, which should be specifically evaluated during the investigation of a suspected thrombocytopathy.
血小板是止血过程中的活跃关键参与者。定性血小板功能障碍会导致血小板病，其特征各异，表现为粘附和促凝血激活终点的缺陷。在本综述中，我们总结了传统的血小板在粘附、分泌和聚集方面的缺陷。此外，我们回顾了关于促凝血血小板的当前知识，重点关注它们在出血或血栓形成性疾病中的作用以及药物调节。促凝血活性是血小板激活的一个重要特征，在怀疑血小板病的调查过程中应进行专门评估。
