LaBresh Kenneth A, Fonarow Gregg C, Smith Sidney C, Bonow Robert O, Smaha Lynn C, Tyler Patricia A, Hong Yuling, Albright Dawn, Ellrodt A Gray
Masspro, Inc, Waltham, Massachusetts, USA.
Crit Pathw Cardiol. 2007 Sep;6(3):98-105. doi: 10.1097/HPC.0b013e31812da7ed.
Adherence to evidence-based interventions for hospitalized cardiovascular disease patients is not optimal. This study assesses the impact of a national quality improvement program on adherence to guidelines in these patients. Data from 92 hospitals from across the United States participating in the Get With The Guidelines program for at least 1 year for 11 acute and secondary prevention measures from a preintervention baseline period and the subsequent 4 quarters of a quality improvement intervention were analyzed. A patient group of 45,988 patients with acute myocardial infarction, unstable angina, revascularization, or peripheral vascular disease was included in this evaluation. Significant improvement from baseline was seen in 10 of 11 measures by the fourth quarter: use of early aspirin for acute myocardial infarction, 76.4% to 88.0% (P < 0.0001); early beta-blocker for acute myocardial infarction, 64.4% to 79.5% (P < 0.0001); beta-blocker at discharge, 75% to 82.1% (P < 0.0001); smoking cessation counseling, 58.7% to 74.3% (P < 0.0001); angiotensin-converting enzyme inhibitor use for acute myocardial infarction, 64.5% to 69.9% (P < 0.0001); lipid treatment, 58.5% to 63.4% (P < 0.0001); lipid treatment for low-density lipoprotein > or =100 mg/dL, 60.4% to 67.0% (P < 0.0001); low-density-lipoprotein measurement, 48.8% to 53.2% (P < 0.0001); discharge blood pressure <140/90 mm Hg, 65.9% to 68.0% (P = 0.03); and referral to cardiac rehabilitation or exercise counseling, 65.0% to 88.3% (P < 0.001). Discharge aspirin use at 89.9% did not change. Statistically and clinically significant improvement in 10 of 11 quality-improvement measures for the treatment of patients hospitalized for cardiovascular disease was seen in hospitals participating in Get With The Guidelines.
住院心血管疾病患者对循证干预措施的依从性并不理想。本研究评估了一项全国性质量改进项目对这些患者遵循指南情况的影响。分析了来自美国各地92家医院的数据,这些医院参与“遵循指南”项目至少1年,数据涵盖11项急性和二级预防措施的干预前基线期以及质量改进干预后的随后4个季度。本评估纳入了一个由45988例急性心肌梗死、不稳定型心绞痛、血管重建或外周血管疾病患者组成的患者组。到第四季度时,11项措施中有10项较基线有显著改善:急性心肌梗死患者早期使用阿司匹林的比例从76.4%升至88.0%(P<0.0001);急性心肌梗死患者早期使用β受体阻滞剂的比例从64.4%升至79.5%(P<0.0001);出院时使用β受体阻滞剂的比例从75%升至82.1%(P<0.0001);戒烟咨询比例从58.7%升至74.3%(P<0.0001);急性心肌梗死患者使用血管紧张素转换酶抑制剂的比例从64.5%升至69.9%(P<0.0001);血脂治疗比例从58.5%升至63.4%(P<0.0001);低密度脂蛋白≥100mg/dL时的血脂治疗比例从60.4%升至67.0%(P<0.0001);低密度脂蛋白测量比例从48.8%升至53.2%(P<0.0001);出院时血压<140/90mmHg的比例从65.9%升至68.0%(P=0.03);转介至心脏康复或运动咨询的比例从65.0%升至88.3%(P<0.001)。出院时阿司匹林使用率为89.9%,未发生变化。参与“遵循指南”项目的医院在治疗住院心血管疾病患者的11项质量改进措施中有10项在统计学和临床上有显著改善。