Thompson R C, Reynoldson J A, Manger B R
School of Veterinary Studies, Murdoch University, Western Australia.
Res Vet Sci. 1991 Nov;51(3):332-4. doi: 10.1016/0034-5288(91)90087-5.
In vitro, epsiprantel at a concentration of 10 micrograms ml-1 caused tegumental damage and death of protoscoleces, juveniles (seven-day-old) and adult (37-day-old) Echinococcus granulosus. Degenerative changes and death occurred more rapidly in the older parasites. Similarly, epsiprantel was more effective against adult (28-day-old) than seven-day-old experimental infections of E granulosus in dogs. Oral doses of 2.5, 5 and 7.5 mg kg-1 were greater than 96 per cent, 99.9 per cent and 99.99 per cent active, respectively, against mature worms, whereas in seven-day-old infections doses of 5, 7.5 and 10 mg kg-1 produced greater than 94 per cent, 90 per cent and 99.8 per cent reduction in worm burdens, respectively. No side effects from treatment were seen.
在体外，浓度为10微克/毫升的埃普西普拉唑可导致细粒棘球绦虫原头节、幼虫（7日龄）和成虫（37日龄）的皮层损伤和死亡。老龄寄生虫的退行性变化和死亡发生得更快。同样，埃普西普拉唑对犬体内28日龄的细粒棘球绦虫成虫感染比对7日龄的感染更有效。口服剂量为2.5、5和7.5毫克/千克时，对成熟虫体的活性分别大于96%、99.9%和99.99%，而在7日龄感染中，5、7.5和10毫克/千克的剂量分别使虫体负荷减少大于94%、90%和99.8%。未观察到治疗的副作用。
