Manger B R, Brewer M D
Br Vet J. 1989 Jul-Aug;145(4):384-8. doi: 10.1016/0007-1935(89)90038-9.
The anthelmintic potential of epsiprantel, 2-(cyclohexylcarbonyl)-4-oxo-1,2,3,4,6,7,8,12b-octahydropyrazin [2,1-a] [2]benzapine, was revealed using the tapeworms Dipylidium caninum and Taenia taeniaeformis in the cat, and Taenia pisiformis and T. hydatigena in the dog. Subsequent controlled tests in cats demonstrated oral efficacy of 100% against D. caninum with a single dose of 2.5 mg/kg. Although consistently 100% effective against T. taeniaeformis at 5 mg/kg, a single worm was found in one cat treated at 7.5 mg/kg. In experimental infections of Taenia pisiformis in dogs, 100% activity was achieved from a single oral dose of 1 mg/kg. No adverse reaction or drug-associated toxicity were observed at dose levels used.
使用猫体内的犬复孔绦虫和豆状带绦虫，以及狗体内的犬豆状绦虫和泡状带绦虫，揭示了埃普西普拉唑（2-(环己基羰基)-4-氧代-1,2,3,4,6,7,8,12b-八氢吡嗪并[2,1-a][2]苯并氮杂卓）的驱虫潜力。随后在猫身上进行的对照试验表明，单剂量2.5mg/kg口服对犬复孔绦虫的疗效为100%。虽然在5mg/kg时对豆状带绦虫始终有效率达100%，但在一只接受7.5mg/kg治疗的猫体内发现了一条虫。在犬豆状绦虫的实验性感染中，单剂量口服1mg/kg的活性为100%。在所使用的剂量水平下未观察到不良反应或药物相关毒性。
