Lopes C A, Moreno G
Department of Microbiology and Immunology, Estadual Paulista University, UNESP, Botucatu-SP, Brazil.
Res Vet Sci. 1991 Nov;51(3):339-40. doi: 10.1016/0034-5288(91)90089-7.
This report compares the in vitro activity of three cephalosporins (cephalothin, cefoxitin and ceftriaxone) against 57 Staphylococcus aureus strains isolated from cows with clinical mastitis on the basis of the minimal inhibitory (MIC) and minimal bactericidal concentrations (MBC). The majority of the S aureus strains showed resistance to cefoxitin and ceftriaxone and sensitivity to cephalothin. The highest MICs and MBCs were found for cefoxitin and ceftriaxone. Antimicrobial tolerance (MBC/MIC greater than or equal to 32:1) was observed in relation to cephalothin and ceftriaxone. The data suggest that these cephalosporins may not be effective for the treatment of staphylococcal bovine mastitis. The precise definition of their antimicrobial efficacies requires more detailed in vitro and in vivo studies.
本报告基于最小抑菌浓度（MIC）和最小杀菌浓度（MBC），比较了三种头孢菌素（头孢噻吩、头孢西丁和头孢曲松）对从患有临床乳腺炎的奶牛中分离出的57株金黄色葡萄球菌菌株的体外活性。大多数金黄色葡萄球菌菌株对头孢西丁和头孢曲松耐药，而对头孢噻吩敏感。头孢西丁和头孢曲松的MIC和MBC最高。观察到与头孢噻吩和头孢曲松相关的抗菌耐受性（MBC/MIC大于或等于32:1）。数据表明，这些头孢菌素可能对治疗牛葡萄球菌性乳腺炎无效。其抗菌效力的确切定义需要更详细的体外和体内研究。
