Park-Wyllie Laura Y, Levine Mitchell A, Holbrook Anne, Thabane Lehana, Antoniou Tony, Yoong Deborah, Kam Derek, Bayoumi Ahmed M
Centre for Research on Inner City Health, The Keenan Research Centre in the Li Ka Shing Knowledge Institute, University of Toronto, Toronto, Ontario, Canada.
Clin Infect Dis. 2007 Oct 1;45(7):933-6. doi: 10.1086/521252. Epub 2007 Aug 20.
Dosage adjustments are often used to manage HIV drug interactions, but little is known about their clinical significance. We examined patients from the Ontario HIV Cohort Study to assess the effects of dosage adjustments on plasma viral load. A significant reduction (0.67 log10 copies/mL) in viral load was associated with adjustments to manage efavirenz-based interactions (95% confidence interval, -1.33 to -0.01) but was not observed after adjustments to manage rifabutin-based (difference in viral load, 0.03 log10 copies/mL; 95% confidence interval, -0.71 to 0.77) or nevirapine-based interactions (difference in viral load, 0.09 log10 copies/mL; 95% confidence interval, -0.83 to 1.01).
剂量调整常用于处理艾滋病毒药物相互作用，但对其临床意义了解甚少。我们研究了安大略艾滋病毒队列研究中的患者，以评估剂量调整对血浆病毒载量的影响。与基于依非韦伦的相互作用管理调整相关的病毒载量显著降低（0.67 log10拷贝/毫升）（95%置信区间，-1.33至-0.01），但在基于利福布汀的相互作用管理调整（病毒载量差异，0.03 log10拷贝/毫升；95%置信区间，-0.71至0.77）或基于奈韦拉平的相互作用管理调整（病毒载量差异，0.09 log10拷贝/毫升；95%置信区间，-0.83至1.01）后未观察到这种情况。
