• 文献检索
  • 文档翻译
  • 深度研究
  • 学术资讯
  • Suppr Zotero 插件Zotero 插件
  • 邀请有礼
  • 套餐&价格
  • 历史记录
应用&插件
Suppr Zotero 插件Zotero 插件浏览器插件Mac 客户端Windows 客户端微信小程序
定价
高级版会员购买积分包购买API积分包
服务
文献检索文档翻译深度研究API 文档MCP 服务
关于我们
关于 Suppr公司介绍联系我们用户协议隐私条款
关注我们

Suppr 超能文献

核心技术专利:CN118964589B侵权必究
粤ICP备2023148730 号-1Suppr @ 2026

文献检索

告别复杂PubMed语法,用中文像聊天一样搜索,搜遍4000万医学文献。AI智能推荐,让科研检索更轻松。

立即免费搜索

文件翻译

保留排版,准确专业,支持PDF/Word/PPT等文件格式,支持 12+语言互译。

免费翻译文档

深度研究

AI帮你快速写综述,25分钟生成高质量综述,智能提取关键信息,辅助科研写作。

立即免费体验

口腔颌面部裂隙易感性相关危险因素——综述

Risk factors involved in orofacial cleft predisposition - review.

作者信息

Kawalec Agata, Nelke Kamil, Pawlas Krystyna, Gerber Hanna

机构信息

Wroclaw Medical University, Wrocław, Poland, Department of Hygiene, Silesian Piast's Medical University, Poland.

Department of Maxillo-Facial Surgery, Silesian Piast's Medical University, Poland.

出版信息

Open Med (Wars). 2015 Feb 5;10(1):163-175. doi: 10.1515/med-2015-0027. eCollection 2015.

DOI:10.1515/med-2015-0027
PMID:28352691
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC5152966/
Abstract

Clefts that occur in children are a special topic. Avoiding risk factors, and also an early diagnosis of cleft possibility can result in minimizing or avoiding them. If on the other hand when clefts occur they require a long-term, multistage specialized treatment. Etiology of clefts seems to be related to many factors. Factors such as genetic, environmental, geographic and even race factors are important. Identification of risk factors can lead to prevention and prophylactic behaviors in order to minimize its occurrence. Exposure to environmental factors at home and work that lead to cleft predisposition should not be disregarded. It seems that before planning a family it would be wise to consult with doctors of different specializations, especially in high-risk families with cleft history in order to analyze previous lifestyle. Clefts are very common in hereditary facial malformations and are causing a lot of other irregularities in the head and neck region. In this paper after a brief papers review authors present socio-geographic, environmental and also work place related factors that are influencing pregnant women condition and should be taken under serious consideration.

摘要

儿童出现的腭裂是一个特殊的话题。避免风险因素以及早期诊断腭裂发生的可能性可将其影响降至最低或避免其发生。另一方面,如果出现腭裂,则需要长期、多阶段的专业治疗。腭裂的病因似乎与许多因素有关。诸如遗传、环境、地理甚至种族等因素都很重要。识别风险因素可促成预防和预防行为,以尽量减少其发生。在家中和工作场所接触导致腭裂易感性的环境因素不容忽视。在计划要孩子之前,咨询不同专业的医生似乎是明智的,特别是对于有腭裂家族史的高风险家庭,以便分析以前的生活方式。腭裂在遗传性面部畸形中非常常见,并且会导致头颈部区域出现许多其他异常情况。在本文中,作者在简要回顾相关文献后,介绍了影响孕妇状况且应予以认真考虑的社会地理、环境以及工作场所相关因素。

相似文献

1
Risk factors involved in orofacial cleft predisposition - review.口腔颌面部裂隙易感性相关危险因素——综述
Open Med (Wars). 2015 Feb 5;10(1):163-175. doi: 10.1515/med-2015-0027. eCollection 2015.
2
The Global Occurrences of Cleft Lip and Palate in Pediatric Patients and Their Association with Demographic Factors: A Narrative Review.小儿患者唇腭裂的全球发病率及其与人口统计学因素的关联:一项叙述性综述
Children (Basel). 2024 Mar 8;11(3):322. doi: 10.3390/children11030322.
3
Orofacial clefts embryology, classification, epidemiology, and genetics.口面裂的胚胎学、分类、流行病学和遗传学。
Mutat Res Rev Mutat Res. 2021 Jan-Jun;787:108373. doi: 10.1016/j.mrrev.2021.108373. Epub 2021 Feb 28.
4
Orofacial clefts: Reflections on prenatal diagnosis and family history based on a series of cases of a tertiary children hospital.口腔颌面裂:基于一家三级儿童医院的一系列病例对产前诊断和家族史的思考
Congenit Anom (Kyoto). 2023 Nov;63(6):195-199. doi: 10.1111/cga.12538. Epub 2023 Aug 31.
5
IRF6 polymorphisms in Brazilian patients with non-syndromic cleft lip with or without palate.巴西非综合征型唇裂伴或不伴腭裂患者的 IRF6 多态性。
Braz J Otorhinolaryngol. 2020 Nov-Dec;86(6):696-702. doi: 10.1016/j.bjorl.2019.04.011. Epub 2019 Jun 8.
6
Associated Malformations in Children with Orofacial Clefts in Portugal: A 31-Year Study.葡萄牙口面部裂隙患儿的相关畸形:一项为期31年的研究。
Plast Reconstr Surg Glob Open. 2018 Feb 9;6(2):e1635. doi: 10.1097/GOX.0000000000001635. eCollection 2018 Feb.
7
An assessment of orofacial clefts in Tanzania.坦桑尼亚的口面裂评估。
BMC Oral Health. 2011 Feb 2;11:5. doi: 10.1186/1472-6831-11-5.
8
Orofacial clefts at Bugando Medical Centre: associated factors and postsurgical complications.布甘多医疗中心的口面部裂隙:相关因素及术后并发症
Cleft Palate Craniofac J. 2012 Nov;49(6):736-40. doi: 10.1597/10-202. Epub 2011 Aug 1.
9
Genetic factors influencing risk to orofacial clefts: today's challenges and tomorrow's opportunities.影响口腔颌面裂隙风险的遗传因素:当今的挑战与未来的机遇。
F1000Res. 2016 Nov 30;5:2800. doi: 10.12688/f1000research.9503.1. eCollection 2016.
10
Maternal obesity is a risk factor for orofacial clefts: a meta-analysis.母亲肥胖是口面部裂隙的一个风险因素:一项荟萃分析。
Br J Oral Maxillofac Surg. 2015 Oct;53(8):699-704. doi: 10.1016/j.bjoms.2015.05.017. Epub 2015 Jun 12.

引用本文的文献

1
Epidemiological pattern of cleft lip and palate under Rashtriya Bal Swasthya Karyakram project in the state of Bihar: A cross-sectional hospital-based study.比哈尔邦“国家儿童健康计划”下唇腭裂的流行病学模式:一项基于医院的横断面研究。
J Family Med Prim Care. 2025 Jul;14(7):2842-2846. doi: 10.4103/jfmpc.jfmpc_1643_24. Epub 2025 Jul 21.
2
Risk Factors for Nonsyndromic Orofacial Clefts Among Saudi Children.沙特儿童非综合征性口腔颌面裂隙的危险因素
Clin Exp Dent Res. 2025 Feb;11(1):e70108. doi: 10.1002/cre2.70108.
3
Orofacial Cleft and Its Association with Consanguineous Marriage and Other Risk Factors: A Case-control Study from a Tertiary Care Hospital in Jammu Province.口腔颌面裂及其与近亲结婚和其他风险因素的关联:来自查谟省一家三级护理医院的病例对照研究
Int J Clin Pediatr Dent. 2024 Nov;17(11):1258-1264. doi: 10.5005/jp-journals-10005-3004. Epub 2024 Dec 19.
4
Neurodevelopmental disorders in children with cleft lip and palate: a systematic review.唇腭裂患儿的神经发育障碍:一项系统综述。
Eur Child Adolesc Psychiatry. 2024 Dec 26. doi: 10.1007/s00787-024-02636-y.
5
Prenatal exposure to antibiotics and the risk of orofacial clefts: a protocol for a systematic review and meta-analysis.产前暴露于抗生素与口腔面裂风险的关系:一项系统评价和荟萃分析的方案。
BMJ Open. 2024 Nov 19;14(11):e092019. doi: 10.1136/bmjopen-2024-092019.
6
Orofacial Clefts and Maternal Risk Factors: A Population-Based Case-Control Study.口腔颌面裂隙与母亲风险因素:一项基于人群的病例对照研究。
Children (Basel). 2024 Jul 4;11(7):819. doi: 10.3390/children11070819.
7
Diagnostic Methods for the Prenatal Detection of Cleft Lip and Palate: A Systematic Review.唇腭裂产前检测的诊断方法:一项系统评价
J Clin Med. 2024 Apr 3;13(7):2090. doi: 10.3390/jcm13072090.
8
Distribution of maternal risk factors for orofacial cleft in infants in Indonesia: a multicenter prospective study.印度尼西亚婴儿口面部裂隙母亲危险因素的分布:一项多中心前瞻性研究。
Arch Craniofac Surg. 2024 Feb;25(1):11-16. doi: 10.7181/acfs.2023.00521. Epub 2024 Feb 20.
9
Environmental tobacco smoke exposure and non-syndromic orofacial cleft: Systematic review and meta-analysis.环境烟草烟雾暴露与非综合征性口面部裂隙:系统评价与荟萃分析。
Tob Induc Dis. 2023 Jun 12;21:76. doi: 10.18332/tid/163177. eCollection 2023.
10
Influence of Domestic Exposure to Polycyclic Aromatic Hydrocarbons on Women's Periconceptional Stage and Associated Risk of Oral Cleft in Offspring.家庭暴露于多环芳烃对女性围孕期及后代口腔腭裂相关风险的影响。
J Pharm Bioallied Sci. 2022 Jul;14(Suppl 1):S589-S594. doi: 10.4103/jpbs.jpbs_659_21. Epub 2022 Jul 13.

本文引用的文献

1
[Orofacial closure defects: cleft lip and palate. A literature review].[口面部闭合缺陷:唇腭裂。文献综述]
Semergen. 2013 Jul-Aug;39(5):267-71. doi: 10.1016/j.semerg.2012.08.003. Epub 2012 Oct 24.
2
Maternal dietary intake of nitrates, nitrites and nitrosamines and selected birth defects in offspring: a case-control study.母体膳食硝酸盐、亚硝酸盐和亚硝胺摄入与后代特定出生缺陷:病例对照研究。
Nutr J. 2013 Mar 21;12:34. doi: 10.1186/1475-2891-12-34.
3
Descriptive epidemiology of cleft lip and cleft palate in Western Australia.西澳大利亚唇腭裂的描述性流行病学
Birth Defects Res A Clin Mol Teratol. 2013 Feb;97(2):101-8. doi: 10.1002/bdra.23110. Epub 2013 Feb 1.
4
Moving Neighborhoods and Health Research Forward: Using Geographic Methods to Examine the Role of Spatial Scale in Neighborhood Effects on Health.推动邻里与健康研究向前发展:运用地理方法探究空间尺度在邻里对健康影响中的作用。
Ann Assoc Am Geogr. 2012 Sep 1;102(5):986-995. doi: 10.1080/00045608.2012.659621. Epub 2012 Apr 3.
5
Current concepts on the effect of environmental factors on cleft lip and palate.当前关于环境因素对唇腭裂影响的概念。
Int J Oral Maxillofac Surg. 2013 Feb;42(2):177-84. doi: 10.1016/j.ijom.2012.10.008. Epub 2012 Dec 8.
6
Use of corticosteroids in early pregnancy is not associated with risk of oral clefts and other congenital malformations in offspring.早期妊娠使用皮质类固醇与后代口腔裂和其他先天性畸形的风险无关。
Am J Ther. 2014 Mar-Apr;21(2):73-80. doi: 10.1097/MJT.0b013e3182491e02.
7
Epidemiology of cleft lip and palate among Jews and Bedouins in the Negev.内盖夫地区犹太人和贝都因人唇腭裂的流行病学研究
Isr Med Assoc J. 2012 Jun;14(6):378-81.
8
Africa has unique and urgent barriers to cleft care: lessons from practitioners at the Pan-African Congress on Cleft Lip and Palate.非洲在唇腭裂治疗方面存在独特且紧迫的障碍:来自泛非唇腭裂大会从业者的经验教训。
Pan Afr Med J. 2012;12:15. Epub 2012 May 30.
9
Use of folic acid supplements and risk of cleft lip and palate in infants: a population-based cohort study.叶酸补充剂的使用与婴儿唇腭裂风险:基于人群的队列研究。
Br J Gen Pract. 2012 Jul;62(600):e466-72. doi: 10.3399/bjgp12X652328.
10
Maternal exposure to amoxicillin and the risk of oral clefts.母体暴露于阿莫西林与口腔裂的风险。
Epidemiology. 2012 Sep;23(5):699-705. doi: 10.1097/EDE.0b013e318258cb05.