Shiel Robert E, Brennan Sheila F, O'Rourke Laurie G, McCullough Maureen, Mooney Carmel T
Small Animal Clinical Studies Unit, School of Agriculture, Food Science and Veterinary Medicine, University College Dublin, Belfield, Dublin 4, Ireland.
Vet Clin Pathol. 2007 Sep;36(3):274-7. doi: 10.1111/j.1939-165x.2007.tb00223.x.
Greyhound dogs have numerous clinicopathologic differences compared with other dog breeds, most notably in their hematologic profiles. The hematologic differences are likely related to breed; however, the influence of other factors, including age, sex, and training, has not been fully determined.
The aim of this study was to assess hematologic values in young, healthy, pretraining Greyhounds and to determine the effects of age and sex on these findings.
Jugular venous EDTA-anticoagulated blood samples were collected from 43 healthy, pretraining Greyhounds between 5 and 13 months of age. Samples were analyzed within 24 hours of collection on an Abbott CELL-DYN 3500R hematology analyzer. Mean hematologic results for different age groups, and correlation with age and sex were determined for each analyte. Results were compared with adult canine, nonbreed-specific reference intervals.
From the age of 9 to 10 months, Greyhounds had higher HCT, hemoglobin concentration, and RBC counts compared with adult canine reference intervals. Younger Greyhounds (5-6 months) had values comparable with reference intervals. Mean total WBC, neutrophil, lymphocyte, and platelet counts tended to be toward the lower end or below the reference intervals. HCT, hemoglobin concentration, and RBC counts were correlated positively with age, and platelet count was correlated negatively with age. No differences were found based on sex.
These results confirm that significant hematologic differences exist in pretraining Greyhounds by 9 to 10 months of age, when compared with adult canine, nonbreed-specific reference intervals; however, these differences are less marked in Greyhounds 5 to 6 months old. Given these findings, it is unlikely that factors such as training or racing are responsible for differences in hematologic values between adult Greyhounds and other breeds.
与其他犬种相比，灵缇犬有许多临床病理差异，最显著的是其血液学特征。血液学差异可能与品种有关；然而，包括年龄、性别和训练在内的其他因素的影响尚未完全确定。
本研究的目的是评估年轻、健康、训练前的灵缇犬的血液学值，并确定年龄和性别对这些结果的影响。
从43只年龄在5至13个月之间的健康、训练前的灵缇犬采集颈静脉乙二胺四乙酸抗凝血液样本。样本在采集后24小时内用雅培CELL-DYN 3500R血液分析仪进行分析。确定不同年龄组的平均血液学结果，以及每种分析物与年龄和性别的相关性。将结果与成年犬非品种特异性参考区间进行比较。
9至10月龄的灵缇犬与成年犬参考区间相比，血细胞比容、血红蛋白浓度和红细胞计数更高。较年轻的灵缇犬（5至6个月）的值与参考区间相当。平均总白细胞、中性粒细胞、淋巴细胞和血小板计数往往处于参考区间的下限或低于参考区间。血细胞比容、血红蛋白浓度和红细胞计数与年龄呈正相关，血小板计数与年龄呈负相关。未发现基于性别的差异。
这些结果证实，与成年犬非品种特异性参考区间相比，9至10月龄的训练前灵缇犬存在显著的血液学差异；然而，这些差异在5至6月龄的灵缇犬中不太明显。鉴于这些发现，训练或比赛等因素不太可能导致成年灵缇犬与其他品种在血液学值上的差异。
