Bannwarth B, Dehais J
Service de Pharmacologie Clinique, CHR Pellegrin-Carreire et Université de Bordeaux II.
Rev Rhum Mal Osteoartic. 1991 Dec;58(12):879-82.
Experimental investigations suggest that NSAIDs may exert a dose-dependent effect on cartilage metabolism. The cartilage concentrations achieved in vivo may thus be useful for in vitro studies. Unfortunately, the concentrations of NSAIDs in human joint cartilage have been scarcely determined. Moreover, the methodologies used were heterogeneous. Guidelines to further studies are therefore proposed.
