Hess E V, Herman J H
Am J Med. 1986 Nov 28;81(5B):36-43.
The issue of selecting nonsteroidal anti-inflammatory drugs (NSAIDs) for the management of osteoarthritis based upon their direct effect on normal cartilage metabolism and their ability to modulate mechanisms that disturb such metabolism is addressed. This article provides an overview of the anatomic and biochemical changes that occur in diseased synovial tissue and cartilage, and the pathophysiologic mechanisms presumed to function in the induction and perpetuation of cartilage failure. Studies using experimental animal models of osteoarthritis are reviewed to evaluate the natural history of the disease, as well as the direct effect of NSAIDs on anabolic and catabolic cartilage function. Experimental evidence strongly indicates that NSAIDs of different classes, as well as members within a given class, function differently and manifest activity in addition to cyclo-oxygenase inhibition.
本文探讨了基于非甾体抗炎药（NSAIDs）对正常软骨代谢的直接作用及其调节干扰这种代谢机制的能力来选择用于骨关节炎治疗的NSAIDs的问题。本文概述了患病滑膜组织和软骨中发生的解剖学和生化变化，以及推测在软骨破坏的诱导和持续过程中起作用的病理生理机制。回顾了使用骨关节炎实验动物模型的研究，以评估该疾病的自然史，以及NSAIDs对软骨合成代谢和分解代谢功能的直接影响。实验证据有力地表明，不同类别的NSAIDs以及给定类别中的成员，其作用方式不同，除了抑制环氧化酶外还表现出活性。
